Английская Википедия:Belotecan
Шаблон:Short description Шаблон:Drugbox
Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for small-cell lung cancer and ovarian cancer, approved in South Korea under the trade name Camtobell, presented in 2 mg vials for injection.[1] The drug has been marketed by Chong Kun Dang Pharmaceuticals[2] since 2003.[3]
Mechanism of action
Belotecan blocks topoisomerase I with a pIC50 of 6.56,[4] stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.[5]
References
Шаблон:Chemotherapeutic agents
Шаблон:Antineoplastic-drug-stub
- Английская Википедия
- Topoisomerase inhibitors
- Delta-lactams
- Delta-lactones
- Nitrogen heterocycles
- Oxygen heterocycles
- Heterocyclic compounds with 5 rings
- Isopropylamino compounds
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