Английская Википедия:Belotecan

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Версия от 21:45, 7 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Chemical compound}} {{Drugbox | Watchedfields = changed | verifiedrevid = 443474638 | IUPAC_name = (4''S'')-4-Ethyl-4-hydroxy-11-[2-(isopropylamino)ethyl]-1''H''-pyrano[3',4':6,7]indolizino[1,2-b]quinoline-3,14(4''H'',12''H'')-dione | image = Belotecan.svg <!--Clinical data--> | tradename = | pregnancy_AU = <!-- A / B1 / B2 / B3 / C / D / X --> | pregnancy_US = <!-...»)
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Belotecan is a drug used in chemotherapy. It is a semi-synthetic camptothecin analogue indicated for small-cell lung cancer and ovarian cancer, approved in South Korea under the trade name Camtobell, presented in 2 mg vials for injection.[1] The drug has been marketed by Chong Kun Dang Pharmaceuticals[2] since 2003.[3]

Mechanism of action

Belotecan blocks topoisomerase I with a pIC50 of 6.56,[4] stabilizing the cleavable complex of topoisomerase I-DNA, which inhibits the religation of single-stranded DNA breaks generated by topoisomerase I; lethal double-stranded DNA breaks occur when the topoisomerase I-DNA complex is encountered by the DNA replication machinery, DNA replication is disrupted, and the tumor cell undergoes apoptosis. Topoisomerase I is an enzyme that mediates reversible single-strand breaks in DNA during DNA replication.[5]

References

Шаблон:Reflist

Шаблон:Chemotherapeutic agents

Шаблон:Antineoplastic-drug-stub