Английская Википедия:Ependymin
Шаблон:Cs1 config Шаблон:Short description Шаблон:Infobox protein Ependymin is a glycoprotein found in the cerebrospinal fluid of many teleost fish. The humans homolog is called ependymin related 1 that is encoded by the EPDR1 gene.
Ependymin is associated with the consolidation of long-term memory, possibly providing protection from strokes, and contributing to neuronal regeneration.[1] This encoded protein was originally detected in elevated amounts of fluid within the central nervous system of teleost fishes.[2] Along with long-term memory and neuronal regeneration, ependymin has been connected to specific aspects of changes in signaling within nerve cells leading to brain plasticity,[3] as well as behavioral performance in response to environment stress in fishes.[4] For example, this glycoprotein interaction in the extracellular matrix influences cell adhesion and migration processes in the central nervous system of teleost fishes.[5] The presence of ependymin-related proteins can be found in both vertebrates and invertebrates.[6] They have variety of functional roles in non-neural sites of organisms.[6] For example, an ependymin-related gene that is upregulated in colon cancer known as UCC1 was found in human colorectal tumor cells.[7]
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