Просмотр кода страницы Английская Википедия:3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase

{{Английская Википедия/Панель перехода}}
{{Short description|Class of enzymes}}
{{infobox enzyme
| Name       = 3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase
| EC_number  = 1.13.11.25
| CAS_number = 37256-63-6
| GO_code    = 0047071
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione 4,5-dioxygenase''' ({{EC number|1.13.11.25}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione + O<sub>2</sub> <math>\rightleftharpoons</math> 3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate

Thus, the two [[substrate (biochemistry)|substrates]] of this enzyme are [[3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione]] and [[oxygen|O<sub>2</sub>]], whereas its [[product (chemistry)|product]] is [[3-hydroxy-5,9,17-trioxo-4,5:9,10-disecoandrosta-1(10),2-dien-4-oate]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on single donors with O<sub>2</sub> as oxidant and incorporation of two atoms of oxygen into the substrate (oxygenases). The oxygen incorporated need not be derived from O<sub>2</sub>.  The [[List of enzymes|systematic name]] of this enzyme class is '''3,4-dihydroxy-9,10-secoandrosta-1,3,5(10)-triene-9,17-dione:oxygen 4,5-oxidoreductase (decyclizing)'''. Other names in common use include '''steroid 4,5-dioxygenase''', and '''3-alkylcatechol 2,3-dioxygenase'''.  It employs one [[cofactor (biochemistry)|cofactor]], [[iron]].

== References ==
{{reflist|1}}
* {{cite journal | vauthors = Gibson DT, Wang KC, Sih CJ, Whitlock H | title = Mechanisms of steroid oxidation by microorganisms. IX. On the mechanism of ring A cleavage in the degradation of 9,10-seco steroids by microorganisms | journal = The Journal of Biological Chemistry | volume = 241 | issue = 3 | pages = 551–9 | date = February 1966 | pmid = 5908121 }}

{{Monooxygenases}}
{{Enzymes}}
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[[Category:EC 1.13.11]]
[[Category:Iron enzymes]]
[[Category:Enzymes of unknown structure]]
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