Просмотр кода страницы Английская Википедия:3alpha,7alpha,12alpha-trihydroxy-5beta-cholest-24-enoyl-CoA hydratase

{{Английская Википедия/Панель перехода}}
{{Short description|Enzyme}}
{{infobox enzyme
| Name       = 3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase
| EC_number  = 4.2.1.107
| CAS_number =
| GO_code    = 
| image      = 
| width      = 
| caption    =  
}}
The [[enzyme]] '''3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA hydratase''' ({{EnzExplorer|4.2.1.107}}) [[catalysis|catalyzes]] the [[chemical reaction]]

:(24''R'',25''R'')-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl-CoA <math>\rightleftharpoons</math>
:::(24''E'')-3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA + H<sub>2</sub>O

== Nomenclature ==

This enzyme belongs to the family of [[lyase]]s, specifically the hydro-lyases, which cleave carbon-oxygen bonds.  The [[List of enzymes|systematic name]] of this enzyme class is (24''R'',25''R'')-3α,7α,12α,24-tetrahydroxy-5beta-cholestanoyl-CoA hydro-lyase [(24''E'')-3α,7α,12α-trihydroxy-5β-cholest-24-enoyl-CoA-forming]. Other names in common use include 46 kDa hydratase 2, and (24''R'',25''R'')-3α,7α,12α,24-tetrahydroxy-5β-cholestanoyl-CoA hydro-lyase.

== References ==
{{reflist}}

== Further reading ==
{{refbegin|32em}}
* {{cite journal | vauthors = Qin YM, Haapalainen AM, Conry D, Cuebas DA, Hiltunen JK, Novikov DK | title = Recombinant 2-enoyl-CoA hydratase derived from rat peroxisomal multifunctional enzyme 2: role of the hydratase reaction in bile acid synthesis | journal = The Biochemical Journal | volume = 328 | issue = 2 | pages = 377–82 | date = December 1997 | pmid = 9371691 | pmc = 1218931 | doi = 10.1042/bj3280377 }}
* {{cite journal | vauthors = Xu R, Cuebas DA | title = The reactions catalyzed by the inducible bifunctional enzyme of rat liver peroxisomes cannot lead to the formation of bile acids | journal = Biochemical and Biophysical Research Communications | volume = 221 | issue = 2 | pages = 271–8 | date = April 1996 | pmid = 8619845 | doi = 10.1006/bbrc.1996.0585 }}
* {{cite journal |author1 = Kokawa NI |author2 =Morisaki M | date = 1988 | title = Synthesis and determination of stereochemistry of four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid | journal = Chem. Pharm. Bull.  | volume = 36 | pages = 134&ndash;141 | doi=10.1248/cpb.36.134| doi-access = free }}
* {{cite journal |author1 = Sonoda Y |author2 =Sato Y |author3 =Morisaki M | date = 1988 | title = Non-stereoselective conversion of the four diastereoisomers at the C-24 and C-25 positions of 3alpha,7alpha,12alpha,24-tetrahydroxy-5beta-cholestan-26-oic acid and cholic acid | journal = Chem. Pharm. Bull.  | volume = 36 | pages = 142&ndash;145 | doi=10.1248/cpb.36.142| doi-access = free }}
* {{cite journal | vauthors = Kurosawa T, Sato M, Nakano H, Fujiwara M, Murai T, Yoshimura T, Hashimoto T | title = Conjugation reactions catalyzed by bifunctional proteins related to beta-oxidation in bile acid biosynthesis | journal = Steroids | volume = 66 | issue = 2 | pages = 107–14 | date = February 2001 | pmid = 11146090 | doi = 10.1016/S0039-128X(00)00217-8 }}
* {{cite journal | vauthors = Russell DW | title = The enzymes, regulation, and genetics of bile acid synthesis | journal = Annual Review of Biochemistry | volume = 72 | pages = 137–74 | date = 2003 | pmid = 12543708 | doi = 10.1146/annurev.biochem.72.121801.161712 }}
{{refend}}

{{Carbon-oxygen lyases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 4.2.1]]
[[Category:Enzymes of unknown structure]]


{{4.2-enzyme-stub}}
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