Просмотр кода страницы Английская Википедия:Carboxypeptidase B

{{Английская Википедия/Панель перехода}}
{{Short description|Class of enzymes}}
{{cs1 config|name-list-style=vanc}}
{{protein
|Name=carboxypeptidase B1 (tissue)
|caption=
|image=
|width=
|HGNCid=2299
|Symbol=CPB1
|AltSymbols=
|EntrezGene=1360
|OMIM=114852
|RefSeq=NM_001871
|UniProt=P15086
|PDB=
|ECnumber=3.4.17.2
|Chromosome=3
|Arm=q
|Band=24
|LocusSupplementaryData=
}}
{{protein
|Name=[[carboxypeptidase B2|carboxypeptidase B2 (plasma)]]
|caption=
|image=
|width=
|HGNCid=2300
|Symbol=CPB2
|AltSymbols=
|EntrezGene=1361
|OMIM=603101
|RefSeq=NM_016413
|UniProt=Q96IY4
|PDB=
|ECnumber=
|Chromosome=13
|Arm=q
|Band=14.11
|LocusSupplementaryData=
}}
{{enzyme
| Name = carboxypeptidase B
| EC_number = 3.4.17.2
| CAS_number = 
| IUBMB_EC_number = 
| GO_code = 0004180
| image = 
| width = 
| caption = 
}}
'''Carboxypeptidase B''' ({{EC number|3.4.17.2}}, ''protaminase'', ''pancreatic carboxypeptidase B'', ''tissue carboxypeptidase B'', ''peptidyl-L-lysine [L-arginine]hydrolase'') is a [[carboxypeptidase]] that preferentially cleaves off basic [[amino acids]] [[arginine]] and [[lysine]] from the C-terminus of a peptide.<ref>{{cite book | title = Proteolytic Enzymes | vauthors = Folk JE | chapter = Carboxypeptidase B (Porcine Pancreas) |series = Methods Enzymol. |year = 1970 |volume = 19 |pages = 504–508 |doi=10.1016/0076-6879(70)19036-7| isbn = 9780121818814 }}</ref><ref>{{cite journal | vauthors = Brodrick JW, Geokas MC, Largman C | title = Human carboxypeptidase B. II. Purification of the enzyme from pancreatic tissue and comparison with the enzymes present in pancreatic secretion | journal = Biochimica et Biophysica Acta (BBA) - Enzymology | volume = 452 | issue = 2 | pages = 468–81 | date = December 1976 | pmid = 1009123 | doi = 10.1016/0005-2744(76)90197-2 }}</ref><ref>{{cite journal | vauthors = Butterworth J, Duncan JJ | title = Carboxypeptidase B activity of cultured skin fibroblasts and relationship to cystic fibrosis | journal = Clinica Chimica Acta; International Journal of Clinical Chemistry | volume = 97 | issue = 1 | pages = 39–43 | date = September 1979 | pmid = 40714 | doi = 10.1016/0009-8981(79)90023-8 }}</ref><ref>{{cite journal | vauthors = Wallace EF, Evans CJ, Jurik SM, Mefford IN, Barchas JD | title = Carboxypeptidase B activity from adrenal medulla--is it involved in the processing of proenkephalin? | journal = Life Sciences | volume = 31 | issue = 16–17 | pages = 1793–6 | year = 1982 | pmid = 6130442 | doi = 10.1016/0024-3205(82)90212-0 }}</ref>  This [[enzyme]] is secreted by the pancreas, and it travels to the small intestine, where it aids in protein digestion. Plasma carboxypeptidase B (carboxypeptidase B2) is responsible for converting the [[Complement component 5a|C5a]] [[protein]] into C5a des-Arg, with one less amino acid.

== References ==
{{reflist}}

== External links ==
* The [[MEROPS]] online database for peptidases and their inhibitors: [http://merops.sanger.ac.uk/cgi-bin/merops.cgi?id=M14.003 M14.003]
* {{MeshName|Carboxypeptidase+B}}

{{Proteases}}
{{Enzymes}}
{{Portal|Biology}}

[[Category:EC 3.4.17]]
[[Category:Metabolism]]
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[[Категория:Английская Википедия]]
[[Категория:Википедия]]
[[Категория:Статья из Википедии]]
[[Категория:Статья из Английской Википедии]]