Просмотр кода страницы Английская Википедия:Cholesterol 7alpha-monooxygenase

{{Английская Википедия/Панель перехода}}
{{Short description|Enzyme}}
{{infobox enzyme
| Name       = cholesterol 7-alpha-monooxygenase
| EC_number  = 1.14.13.17
| CAS_number = 9037-53-0
| GO_code    = 0008123
| image      =
| width      = 
| caption    =  
}}
In [[enzymology]], a '''cholesterol 7alpha-monooxygenase''' ({{EC number|1.14.13.17}}) is an [[enzyme]] that [[catalysis|catalyzes]] the [[chemical reaction]]

:cholesterol + NADPH + H<sup>+</sup> + O<sub>2</sub> <math>\rightleftharpoons</math> 7alpha-hydroxycholesterol + NADP<sup>+</sup> + H<sub>2</sub>O

The 4 [[substrate (biochemistry)|substrates]] of this enzyme are [[cholesterol]], [[nicotinamide adenine dinucleotide phosphate|NADPH]], [[hydrogen ion|H<sup>+</sup>]], and [[oxygen|O<sub>2</sub>]], whereas its 3 [[product (chemistry)|products]] are [[7-alpha-hydroxycholesterol]], [[nicotinamide adenine dinucleotide phosphate|NADP<sup>+</sup>]], and [[water|H<sub>2</sub>O]].

This enzyme belongs to the family of [[oxidoreductase]]s, specifically those acting on paired donors, with O2 as oxidant and incorporation or reduction of oxygen. The oxygen incorporated need not be derived from O2 with NADH or NADPH as one donor, and incorporation of one atom o oxygen into the other donor.  The [[List of enzymes|systematic name]] of this enzyme class is '''cholesterol,NADPH:oxygen oxidoreductase (7alpha-hydroxylating)'''. Other names in common use include '''cholesterol 7alpha-hydroxylase''', and '''CYP7A1'''.  This enzyme participates in [[bile acid biosynthesis]] and [[Peroxisome proliferator-activated receptor|ppar signaling pathway]].  It employs one [[cofactor (biochemistry)|cofactor]], [[heme]].

==References==
{{reflist|1}}
* {{cite journal |vauthors=Boyd GS, Grimwade AM, Lawson ME | date = 1973 | title = Studies on rat-liver microsomal cholesterol 7alpha-hydroxylase | journal = Eur. J. Biochem.  | volume = 37 | pages = 334&ndash;40  | pmid = 4147676 | doi = 10.1111/j.1432-1033.1973.tb02992.x | issue = 2 | doi-access =  }}
* {{cite journal |vauthors=Mitton JR, Scholan NA, Boyd GS | date = 1971 | title = The oxidation of cholesterol in rat liver sub-cellular particles The cholesterol-7-alpha-Hydroxylase enzyme system | journal = Eur. J. Biochem.  | volume = 20 | pages = 569&ndash;79  | pmid = 4397276 | doi = 10.1111/j.1432-1033.1971.tb01429.x | issue = 4 }}
* {{cite journal |vauthors=Ogishima T, Deguchi S, Okuda K | date = 1987 | title = Purification and characterization of cholesterol 7 alpha-hydroxylase from rat liver microsomes | journal = J. Biol. Chem.  | volume = 262 | pages = 7646&ndash;50  | pmid = 3584134 | issue = 16 }}

{{Dioxygenases}}
{{Enzymes}}
{{Portal bar|Biology|border=no}}

[[Category:EC 1.14.13]]
[[Category:NADPH-dependent enzymes]]
[[Category:Heme enzymes]]
[[Category:Enzymes of unknown structure]]


{{1.14.13-enzyme-stub}}
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