Просмотр кода страницы Английская Википедия:Hepatitis C virus envelope glycoprotein E2

{{Английская Википедия/Панель перехода}}
[[Image:HCV genome.png|thumb|HCV genome]]
'''E2''' is a [[viral structural protein]] found in the [[hepatitis C virus]].<ref name="pmid11830338">{{cite journal |vauthors=Garcia JE, Puentes A, Súarez J, López R, Vera R, Rodríguez LE, Ocampo M, Curtidor H, Guzman F, Urquiza M, Patarroyo ME |title=Hepatitis C virus (HCV) E1 and E2 protein regions that specifically bind to HepG2 cells |journal=Journal of Hepatology |volume=36 |issue=2 |pages=254–62 |year=2002 |pmid=11830338 |doi=10.1016/S0168-8278(01)00262-8 }}</ref><ref name="pmid12615904">{{cite journal |vauthors=Bartosch B, Dubuisson J, Cosset FL |title=Infectious hepatitis C virus pseudo-particles containing functional E1-E2 envelope protein complexes |journal=The Journal of Experimental Medicine |volume=197 |issue=5 |pages=633–42 |year=2003 |pmid= 12615904|pmc=2193821 |doi=10.1084/jem.20021756 |url=http://www.hal.inserm.fr/inserm-00133783/document }}</ref> It is present on the [[viral envelope]] and functions as a host receptor [[binding protein]], mediating entry into [[host cells]]. It is a key target for the design of [[entry inhibitor]]s and vaccine [[immunogen]]s.<ref name= "NCBI E2 (HCV)">{{cite journal |vauthors=Kong L, Giang E, Nieusma T, Kadam RU, Cogburn KE, Hua Y, Dai X, Stanfield RL, Burton DR, Ward AB, Wilson IA, Law M |title=Hepatitis C virus E2 envelope glycoprotein core structure |journal=Science |volume=342 |issue=6162 |pages=1090–4 |year=2013 |pmid=24288331 |pmc=3954638 |doi=10.1126/science.1243876 |bibcode=2013Sci...342.1090K }}</ref>

==References==
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{{Viral proteins}}

[[Category:Viral structural proteins]]
[[Category:Hepatitis C virus]]


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