Английская Википедия:3-Aminobenzamide

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3-Aminobenzamide is a benzamide. It is an off-white powder and has the chemical formula C7H8N2O.

Preparation

3-Aminobenzamide can be prepared through the reduction of 3-nitrobenzamide by catalytic hydrogenation.[1]

Uses

3-Aminobenzamide is an inhibitor of poly ADP ribose polymerase (PARP), an enzyme responsible for DNA repair, transcription control, and programmed cell death.[1] When PARP is activated it rapidly uses up stores of nicotinamide adenine dinucleotide (NADШаблон:+) in the cell as it performs DNA repair. Low levels of NADШаблон:+ deplete the amount of ATP found in the cell which can lead to cell death.[2] The structure of 3-aminobenzamide is similar to that of NADШаблон:+ so it binds to PARP and prevents it from using up NADШаблон:+. PARP is often a target of cancer therapy and so 3-aminobenzamide could potentially be used as an anticancer drug.[3]

References

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