Английская Википедия:Carbamoyl phosphate synthase II

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Шаблон:Infobox enzyme Шаблон:Protein Carbamoyl phosphate synthetase (glutamine-hydrolysing) (Шаблон:EnzExplorer) is an enzyme that catalyzes the reactions that produce carbamoyl phosphate in the cytosol (as opposed to type I, which functions in the mitochondria). Its systemic name is hydrogen-carbonate:L-glutamine amido-ligase (ADP-forming, carbamate-phosphorylating).[1][2][3][4][5][6][7][8]

In pyrimidine biosynthesis, it serves as the rate-limiting enzyme and catalyzes the following reaction:

2 ATP + L-glutamine + HCO3 + H2O <math>\rightleftharpoons</math> 2 ADP + phosphate + L-glutamate + carbamoyl phosphate (overall reaction)
(1a) L-glutamine + H2O <math>\rightleftharpoons</math> L-glutamate + NH3
(1b) 2 ATP + HCO3 + NH3 <math>\rightleftharpoons</math> 2 ADP + phosphate + carbamoyl phosphate

It is activated by ATP and PRPP[9] and it is inhibited by UTP (Uridine triphosphate)[10] Neither CPSI nor CPSII require biotin as a coenzyme, as seen with most carboxylation reactions.

It is one of the three enzyme functions coded by the CAD gene. It is classified under Шаблон:EC number.

See also

References

Шаблон:Reflist

External links

Шаблон:Nucleotide metabolism Шаблон:Multienzyme complexes Шаблон:Ligases CO CS and CN Шаблон:Enzymes Шаблон:Portal bar


Шаблон:6.3-enzyme-stub