Английская Википедия:Cyrus Chothia
Шаблон:Short description Шаблон:EngvarB Шаблон:Use dmy dates Шаблон:Infobox scientistCyrus Homi Chothia (19 February 1942 – 26 November 2019)[1] Шаблон:Post-nominals[2][3] was an English biochemist who was an emeritus scientist at the Medical Research Council (MRC) Laboratory of Molecular Biology (LMB) at the University of Cambridge[4][5] and emeritus fellow of Wolfson College, Cambridge.[2][6][7][8][9][10][11]
Education
Chothia was educated at Alleyn's School,[12] then went to study at Durham University graduating with a Bachelor of Science degree in 1965.[1] Chothia then completed a Master of Science degree at Birkbeck College in 1967 and a PhD from University College London[13] under the supervision of Шаблон:Ill,[14] the son of Linus Pauling.
Research and career
After his PhD Chothia worked in the Laboratory of Molecular Biology (LMB) for three years. He then worked with Michael Levitt[15] at the Weizmann Institute of Science[16][17] followed by two years with Joel Janin at the Institut Pasteur in Paris.[18]
In 1976 Chothia returned to England to work at University College London and the LMB. With Arthur Lesk[19][20] he showed that proteins adapt to mutations by changes in structure.
In 1992 he proposed that most proteins are built of domains that come from a small number of families.[21] He collaborated with Alexey Murzin, Steven Brenner and Tim Hubbard to create the Structural Classification of Proteins database (SCOP),[22][23] a periodic table for all known protein structures. With Julian Gough[24] he created the Superfamily database[25] which uses Hidden Markov models to identify protein sequences that are related to those of known structures.
During his career, Chothia supervised 19 successful PhD students to completion[26] including Alex Bateman,[27] Steven E. Brenner,[28] Mark Bender Gerstein,[29] Julian Gough,[30] Sarah Teichmann,[31] Bissan Al-Lazikani,[32][33][34] Goga Apic,[35] Samantha BarréШаблон:Citation needed[36] Matthew Bashton,[37][38][39][40] Dan Bolser,[41] Michael Bremang,[42] Bernard de Bono,[43][44] Emma Ganley (née Hill),[45][46][47] Martin Madera,[48][49] Siarhei Maslau,[50] Susan Miller,[51][52][53] Jong Park (aka Jong Bhak),[54][55][56] Rajkumar Sasidharan,[57][58] and Christine Vogel.[59][60]
Awards and honours
Chothia was elected a Fellow of the Royal Society (FRS) in 2000.[1] His certificate of election and candidature reads: Шаблон:Centred pull quote
In 2015, Chothia was elected a Fellow of the International Society for Computational Biology (ISCB)[61] and was awarded the ISCB Accomplishment by a Senior Scientist Award in honour of his work in using computational methods to understand protein structure.[62][63]
Alongside David Haussler and Michael Waterman, Chothia was awarded the 2015 Dan David Prize for his contributions to the field of bioinformatics.[64]
References
Шаблон:FRS 2000 Шаблон:ISCB Fellows Шаблон:CC-notice Шаблон:Authority control
- ↑ 1,0 1,1 1,2 Шаблон:Who's Who
- ↑ 2,0 2,1 Шаблон:Cite web
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