Английская Википедия:Efavirenz/lamivudine/tenofovir

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Шаблон:Short description Шаблон:Infobox drug

Efavirenz/lamivudine/tenofovir (EFV/3TC/TDF), sold under the brand name Symfi among others, is a fixed-dose combination antiretroviral medication for the treatment of HIV/AIDS.[1][2][3] It combines efavirenz, lamivudine, and tenofovir disoproxil.[3] Шаблон:As of, it is listed by the World Health Organization as an alternative first line option to dolutegravir/lamivudine/tenofovir.[4] It is taken by mouth.[1][2][3]

Side effects can include joint pain, sleepiness, headaches, depression, trouble sleeping, and itchiness.[3] Severe side effects may include depression, psychosis, or osteonecrosis.[3] In those with a history of epilepsy, it may increase the frequency of seizures.[3] Greater care should also be taken in those with kidney problems.[3] Its use during pregnancy appears to be unsafe.[1][2]

It is on the World Health Organization's List of Essential Medicines.[5] The combination received tentative approval in the United States in 2014,[6] and was granted approval in February 2018.[7][8] Its availability and importance is supported by Medecins Sans Frontieres.[3] It is available as a generic medication.[9][10][11]

References

Шаблон:Reflist

External links

Шаблон:HIVpharm Шаблон:Portal bar


Шаблон:Antiinfective-drug-stub

  1. 1,0 1,1 1,2 Ошибка цитирования Неверный тег <ref>; для сносок Symfi FDA label не указан текст
  2. 2,0 2,1 2,2 Ошибка цитирования Неверный тег <ref>; для сносок Symfi Lo FDA label не указан текст
  3. 3,0 3,1 3,2 3,3 3,4 3,5 3,6 3,7 Шаблон:Cite web
  4. Шаблон:Cite book
  5. Шаблон:Cite book
  6. Шаблон:Cite web
  7. Шаблон:Cite web
  8. Шаблон:Cite web
  9. Шаблон:Cite web
  10. Шаблон:Cite web
  11. Шаблон:Cite web