Английская Википедия:Etirinotecan pegol

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Шаблон:Short description Шаблон:Infobox drug

Etirinotecan pegol (trade name Onzeald) is a drug developed by Nektar Therapeutics for the treatment of certain kinds of breast cancer with brain metastases. The European Medicines Agency refused to grant it a marketing authorisation in 2017.[1]

It works as a topoisomerase I inhibitor.[2] Chemically, it consists of four units of irinotecan (a topoisomerase I inhibitor in use since the late 1990s[3]) linked by carboxymethyl glycine and polyethylene glycol (PEG) chains to a central pentaerythritol ether, resulting in a much longer biological half-life (38 days) than that of irinotecan. It is formulated as a dihydrochloride and with 1.2 units of trifluoroacetate.[4]

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Шаблон:Chemotherapeutic agents Шаблон:Antineoplastic-drug-stub