Английская Википедия:HLA-DR1

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PDB rendering based on 1a6a.
DR1 binding pocket with ligand Шаблон:PDB
major histocompatibility complex, class II, DR1
Haplotypes groups	DRA*01:DRB1*01:01 DRA*01:DRB1*01:02 DRA*01:DRB1*01:03
Structure (See HLA-DR)
Identifiers	alpha *01:01
Symbol(s)	HLA-DRAШаблон:Dead link
EBI-HLA	DRA *01:01
Identifiers	beta 1 *01:01, *01:02, *01:03 . . .
Symbol(s)	HLA-DRB1Шаблон:Dead link
Shared data
Locus	chr.6 6p21.31

HLA-DR1 (DR1) is a HLA-DR serotype that recognizes the DRB1*01 gene products. It has been observed to be common among centenarians.

Serology

DR1 serotype recognition of Some DRB1*01 allele-group gene products

DRB1*	DR1	DR103		Sample
allele	%	%	%	size (N)
Шаблон:HDR1A	97%			6317
Шаблон:HDR1A	95%			2035
Шаблон:HDR1A	56%	12%		1186
Шаблон:HDR1A	>50%			2

The serology for the most common DR1 alleles is excellent. The serology for alleles Шаблон:HDR1A, Шаблон:HDR1A, Шаблон:HDR1A, Шаблон:HDR1A, Шаблон:HDR1A, Шаблон:HDR1A, and Шаблон:HDR1A is unknown.

Disease associations

By serotype

DR1 is associated with seronegative-rheumatoid arthritis, penicillamine-induced myasthenia, and schizophrenia. DR1 is increased in patients with systemic sclerosis and arthritis and in ulcerative colitis with patients that have articular manifestations.

By allele

DRB1*01:01 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, foliaceous pemphigus, HTLV-1-associated myelopathy/tropical spastic paraparesis, and lichen planus. In lyme disease arthritis, *01:01 appears to play a role in presentation of triggering microbial antigens.

DRB1*01:02 is associated with rheumatoid arthritis, in anti-Jk(a) mediated hemolytic transfusion reactions, psoriasis vulgaris, and recurrent respiratory papillomatosis

DRB1*01:03 is associated with colonic Crohn's disease and ulcerative colitis.

By genotype

DRB1*01:01/*0404 and *01:01/*0401 increases risk of mortality in rheumatoid arthritis, with ischemic heart disease and smoking. these same genotypes are associated with rheumatoid vasculitis.

ligand (Staphylococcal enterotoxin 1-C peptide:pkyvkqntlklat) within the binding pocket of DR αβ101

ligand (Staphylococcal enterotoxin 1-C peptide:pkyvkqntlklat) within the binding pocket of DR αβ¹⁰¹

By haplotype

DRB1*01:02:DQB1*05:01 is associated with psoriasis vulgaris and tubulointerstitial nephritis & uveitis syndrome, but is relatively protective against juvenile diabetes.

DR1-DQ5 is associated with tubulointerstitial nephritis & uveitis syndrome.

Rheumatoid arthritis

Шаблон:Clarify There frequency of DR4-DQ8 haplotypes reach extreme nodal levels. Arthritis has been identified in a pre-Columbian remains from Italy, the affected individual bearing the DRB1*01:01 allele. DRB1*01:01 and most DR4 have in common a 'shared epitope'. In this hypothesis a common region of the beta chain, positions 67 to 74, are common and may be integral to presenting auto-immunological peptides.

Genetic linkage

DR1 Haplotypes
Serotypes	DRA	DRB1
DR1	*01:01	*01:01
	*01:01	*01:02
	*01:01	*01:03
Serotypes	DQA1	DQB1	DRB1
DR1-DQ5 (5.1, 1)	*01:01	*05:01	*01:01
	*01:01	*05:01	*01:02
	*01:01	*05:01	*01:03
Serotypes	HLA-A	HLA C	HLA B	DRB1
A3-Cw4-B35-DR1	*03:01	*04:01	*35:01	*01:01
A11-Cw4-B35-DR1	*11:01	*04:01	*35:01	*01:03
A33-Cw8-B14-DR1	*33:01	*08:02	*14:02	*01:02

HLA-DR1 is not genetically linked to DR51, DR52 or DR53, but is linked to HLA-DQ1 and DQ5 serotypes.