Английская Википедия:HLA-DR3
Illustration of an HLA-DR (Human MHC class II) antigen receptor with bound antigen | ||
major histocompatibility complex, class II, DR3
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Haplotypes groups | DRA*01:DRB1*03:01 DRA*01:DRB1*03:02 DRA*01:DRB1*03:03 DRA*01:DRB1*03:04 | |
Structure (See HLA-DR) | ||
Identifiers | alpha *01:01
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Symbol(s) | HLA-DRAШаблон:Dead link | |
EBI-HLA | DRA*01:01 | |
Identifiers | beta 1 *03:01 *03:01 *03:02 *03:03 *03:04
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Symbol(s) | HLA-DRB1Шаблон:Dead link | |
EBI-HLA | DRB1*03:01 | |
EBI-HLA | DRB1*03:02 | |
EBI-HLA | DRB1*03:03 | |
EBI-HLA | DRB1*03:04 | |
EBI-HLA | DRB1*03:05 Шаблон:Webarchive | |
Shared data | ||
Locus | chr.6 6p21.31 |
HLA-DR3 is composed of the HLA-DR17 and HLA-DR18 split 'antigens' serotypes. DR3 is a component gene-allele of the AH8.1 haplotype in Northern and Western Europeans. Genes between B8 and DR3 on this haplotype are frequently associated with autoimmune disease. Type 1 diabetes mellitus is associated with HLA-DR3 or HLA-DR4. Nearly half the US population has either DR3 or DR4 (only 1–3% have both), yet only a small percentage (about 0.5%) of these individuals will develop type 1 diabetes.
Serology
DRB1* | DR3 | DR17 | DR18 | Sample |
allele | % | % | % | size (N) |
03:01 | 33 | 64 | 0 | 9698 |
03:02 | 24 | 3 | 66 | 317 |
03:03 | 40 | 60 | 5 | |
03:04 | 60 | 20 | 5 | |
03:07 | >50 | 1 |
Some DR3 also react with HLA-DR17 and/or HLA-DR18. The DRB1*03:04 primarily reacts with DR3. The serotypes of *03:05, *03:06, *03:08 to *03:31 are unknown.
Disease associations
By serotype
HLA-DR3 is associated with early-age onset myasthenia gravis, Hashimoto's thyroiditis (along with DR5), primary sclerosing cholangitis,[2] and opportunistic infections in AIDS,[3] but lowered risk for cancers.[4] It is also associated with membranous glomerulonephritis[5]
By allele
DRB1*03:01 (see HLA-DR17)
DRB1*03:02 (See HLA-DR18)
DRB1*03:04 is associated with Graves disease[6]
By haplotypes
DR3 and/or DQ2 is associated with Moreen's ulceration,[7] "bout onset" multiple sclerosis,[8] Graves' disease[9] and systemic lupus erythematosus[10]
DR3-DQ2 linkage is associated with coeliac disease, dermatitis herpetiformis, Diabetes mellitus type 1. DR3-DR2 is the serological marker for HLA-DQ2.5cis isoform. Although it cannot identify the alpha ".5" chain of HLA DQ, DQA1*05:01 gene is almost always found within the DR3-DQ2 haplotype Eurasia (however in older studies DQA1*05:05 is commonly confused with DQA1*05:01)
[11]
Genetic linkage
DR3 is genetically linked to HLA-DR52, DRB3*02:02 allele, and HLA-DQ2 (DQ2.5).
References
Шаблон:Reflist Шаблон:DR serotypes