Английская Википедия:Helicase–primase complex

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Шаблон:Cs1 config A helicase–primase complex (also helicase-primase, Hel/Prim, H-P or H/P) is a complex of enzymes including DNA helicase and DNA primase. A helicase-primase associated factor protein may also be present.[1]

The complex is used by herpesviruses, in which it is responsible for lytic DNA virus replication.[2][3][4] In many dsDNA viruses, primase and helicase are fused into a single polypeptide chain, so that the primase and helicase domains correspond to the N-terminal and C-terminal parts of the protein, respectively.[5] A helicase-primase inhibitor (HPI) is a drug that blocks this action through acting as an enzyme inhibitor.

List of H-P by virus name

  • EBV: helicase:BBLF4 primase: BSLF1 accessory protein:BBLF2/3[2]

List of H-P inhibitors

References

Шаблон:Reflist

Шаблон:DNA antivirals


Шаблон:Virus-stub