Английская Википедия:Hypothalamic–pituitary–prolactin axis

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Файл:PRL structure.png
Prolactin, a major hormone of the HPP axis.

The hypothalamic–pituitary–prolactin axis (HPP axis), also known as the hypothalamic–pituitary–mammary axis or hypothalamic–pituitary–breast axis, is a hypothalamic–pituitary axis which includes the secretion of prolactin (PRL; luteotropin) from the lactotrophs of the pituitary gland into the circulation and the subsequent action of prolactin on tissues such as, particularly, the mammary glands or breasts.[1][2] It is involved in lobuloalveolar maturation of the mammary glands during pregnancy and the induction and maintenance of lactation following parturition.[3] Hormones that control the secretion of prolactin from the pituitary gland include dopamine ("prolactin-inhibiting factor", or "PIF"), estradiol, progesterone, thyrotropin-releasing hormone (TRH), and vasoactive intestinal peptide (VIP).[1][4]

See also

References

Шаблон:Reflist

Шаблон:Endocrinology physiology Шаблон:Human reproductive physiology Шаблон:Hormones Шаблон:Prolactin receptor modulators


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