Английская Википедия:1,3,4-Oxadiazole
1,3,4-Oxadiazole is a nitrogen and oxygen containing heterocycle, and one of the four isomers of oxadiazole.[1][2]
Derivatives
1,3,4-Oxadiazole itself is not commonly used in organic chemistry, but many of its derivatives are important. For example, raltegravir is an HIV drug which contains an 1,3,4-oxadiazole ring. Other pharmaceutical drugs containing the 1,3,4-oxadiazole ring include fenadiazole, zibotentan, and tiodazosin.
1,3,4-Oxadiazole derivatives can be synthesized in a variety of ways.[3] One pathway is from oxidation of tetrazoles in the presence of aldehydes.[4] Similarly, the reaction of tetrazoles with acyl chlorides provides oxadiazoles.[5] Both methods involve the release of N2.
See also
- Furazan (1,2,5-oxadiazole)
References
