Английская Википедия:2-Methylnaphthalene-1,4-diamine
Шаблон:Chembox 2-Methylnaphthalene-1,4-diamine is a synthetic menadione analog with vitamin K activity.[1][2]
2-Methylnaphthalene-1,4-diamine was first synthesized in 1925.[3][1] In 1942 two different research groups noted the vitamin K activity of the compound.[1][4][5] It forms a dihydrochloride salt (C11H14Cl2N2) with hydrochloric acid and one of the aforementioned research groups suggested the name vitamin K6 for the salt.[1]
2-Methylnaphthalene-1,4-diamine and its dihydrochloride can be made from 2-methylnaphthalene or its close analogs. Dihydrochloride blackens without melting at about 300 °C.[1]
4-Amino-3-methyl-1-naphthol or its dihydrochloride have not been used as commercial medicinal forms of vitamin K unlike phylloquinone and menadione for example.[6]
Oral toxicity of dihydrochloride for rats is approximately the same as for 4-amino-2-methyl-1-naphthol hydrochloride.[1]
References
Шаблон:Vitamin Шаблон:Antihemorrhagics
