Английская Википедия:2C-T-16
Шаблон:Short description Шаблон:Chembox
2C-T-16 is a lesser-known psychedelic drug. It was originally named by Alexander Shulgin as described in his book PiHKAL (Phenethylamines i Have Known And Loved), however while Shulgin began synthesis of this compound he only got as far as the nitrostyrene intermediate, and did not complete the final synthetic step.[1] Synthesis of 2C-T-16 was finally achieved by Daniel Trachsel some years later,[2] and it was subsequently reported as showing similar psychedelic activity to related compounds, with a dose range of 10–25 mg and a duration of 4–6 hours,[3]Шаблон:Rp making it around the same potency as the better-known saturated analogue 2C-T-7, but with a significantly shorter duration of action. Binding studies in vitro showed 2C-T-16 to have a binding affinity of 44 nM at 5-HT2A and 15 nM at 5-HT2C.[3]Шаблон:Rp 2C-T-16 and related derivatives are potent partial agonists of the 5-HT1A, 5-HT2A, 5-HT2B and 5-HT2C receptors and induce a head-twitch response in mice.[4]
Legality
Canada
As of October 31, 2016, 2C-T-16 is a controlled substance (Schedule III) in Canada.[5]
See also
References
External links
- ↑ Шаблон:CitePiHKAL
- ↑ Шаблон:Cite journal
- ↑ 3,0 3,1 Шаблон:Cite book
- ↑ Luethi D, Trachsel D, Hoener MC, Liechti ME. Monoamine receptor interaction profiles of 4-thio-substituted phenethylamines (2C-T drugs). Neuropharmacology. 2018 May; Volume 134, Part A: 141-148.Шаблон:Cite journal
- ↑ Шаблон:Cite web
