Английская Википедия:3,4,5-Trimethoxybenzaldehyde
3,4,5-Trimethoxybenzaldehyde is an organic compound. Within this class of compounds the chemical is categorized as a trisubstituted aromatic aldehyde.
Uses
3,4,5-Trimethoxybenzaldehyde can be used as an intermediate in the synthesis of some pharmaceutical drugs including trimethoprim,[1][2] cintriamide, roletamide, trimethoquinol (aka tretoquinol), and trimazosin as well as some psychedelic phenethylamines.[3][4][5]
Preparation
Industrial scale
For industrial applications the chemical is synthesized from p-cresol using aromatic substitution with bromine followed by nucleophilic substitution with sodium methoxide.[1] Oxidation of the methyl group to an aldehyde can occur via various synthetic methods.
Laboratory scale
At the laboratory scale the chemical is conveniently synthesized from vanillin[6] or from Eudesmic acid's Acyl chloride via Rosenmund reduction.[7]
References
- ↑ 1,0 1,1 Шаблон:Cite book
- ↑ Stenbuck, P.; Hood, H. M.; 1962, Шаблон:US Patent
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite book
- ↑ Шаблон:Cite journal
- ↑ Шаблон:Cite journal