Английская Википедия:4-Hydroxyphenylacetaldehyde
Шаблон:Use dmy dates Шаблон:Chembox 4-Hydroxyphenylacetaldehyde, also known as p-hydroxyphenylacetaldehyde, is a natural product with the formula HOC6H4CH2CHO. It is a derivative of phenylacetaldehyde and occurs as a white solid at room temperature.[1]
Synthesis
4-Hydroxyphenylacetaldehyde can be synthesized from a parsley tyrosine decarboxylase (L-tyrosine).[2]
Occurrence
4-Hydroxyphenylacetaldehyde is produced from the metabolism of tyramine by monoamine oxidase (MAO) enzymes in humans and the tyramine oxidase (tynA) enzyme in Escherichia coli.[3][4] In both species, it is subsequently metabolized into 4-hydroxyphenylacetate by aldehyde dehydrogenase (ALDH) enzymes in humans and the phenylacetaldehyde dehydrogenase (feaB) enzyme in E. coli.[3][4][5]
The condensation of 4-hydroxyphenylacetaldehyde and dopamine is a key step in the biosynthesis of benzylisoquinoline alkaloids. These natural products include berberine and morphine.[6]
References
Шаблон:Reflist Шаблон:Molecular-cell-biology-stub
