Английская Википедия:4-aminobutyrate—pyruvate transaminase
Шаблон:Short description Шаблон:Infobox enzyme 4-aminobutyrate---pyruvate transaminase (Шаблон:EC number, aminobutyrate aminotransferase, gamma-aminobutyrate aminotransaminase, gamma-aminobutyrate transaminase, gamma-aminobutyric acid aminotransferase, gamma-aminobutyric acid pyruvate transaminase, gamma-aminobutyric acid transaminase, gamma-aminobutyric transaminase, 4-aminobutyrate aminotransferase, 4-aminobutyric acid aminotransferase, aminobutyrate transaminase, GABA aminotransferase, GABA transaminase, GABA transferase, POP2 (gene)) is an enzyme with systematic name 4-aminobutanoate:pyruvate aminotransferase.[1][2][3][4] This enzyme is a type of GABA transaminase, which degrades the neurotransmitter GABA. The enzyme catalyses the following chemical reaction
- (1) 4-aminobutanoate + pyruvate <math>\rightleftharpoons</math> succinate semialdehyde + L-alanine
- (2) 4-aminobutanoate + glyoxylate <math>\rightleftharpoons</math> succinate semialdehyde + glycine
This enzyme requires pyridoxal 5'-phosphate.
Clinical significance
Phenylethylidenehydrazine, the active metabolite of phenelzine, inhibits gamma-aminobutyric acid transaminase and subsequently increases GABA concentrations in the central nervous system. This may contribute to the notable anxiolytic effects of phenelzine.[5]
References
External links
Шаблон:Nitrogenous transferases Шаблон:Enzymes Шаблон:Portal bar
