Английская Википедия:5β-Reductase
Шаблон:Short description Шаблон:Infobox enzyme
5β-Reductase, or Δ4-3-oxosteroid 5β-reductase (Шаблон:EC number, 3-oxo-Δ4-steroid 5β-reductase, androstenedione 5β-reductase, cholestenone 5β-reductase, cortisone 5β-reductase, cortisone Δ4-5β-reductase, steroid 5β-reductase, testosterone 5β-reductase, Δ4-3-ketosteroid 5β-reductase, Δ4-5β-reductase, Δ4-hydrogenase, 4,5β-dihydrocortisone:NADP+ Δ4-oxidoreductase, 3-oxo-5β-steroid:NADP+ Δ4-oxidoreductase) is an enzyme with systematic name 5β-cholestan-3-one:NADP+ 4,5-oxidoreductase.[1][2][3][4][5][6][7][8][9] This enzyme catalyses the following chemical reaction
- (1) 5β-cholestan-3-one + NADP+ <math>\rightleftharpoons</math> cholest-4-en-3-one + NADPH + H+
- (2) 17,21-dihydroxy-5β-pregnane-3,11,20-trione + NADP+ <math>\rightleftharpoons</math> cortisone + NADPH + H+
The human enzyme efficiently acts on progesterone, 17α-hydroxyprogesterone, androstenedione, and testosterone to 5β-reduced metabolites. It can also act on aldosterone, corticosterone and cortisol, to some extent.
See also
References
External links
Шаблон:CH-CH oxidoreductases Шаблон:Enzymes Шаблон:Portal bar
