Английская Википедия:5′-Phosphoribosylformylglycinamidine
5′-Phosphoribosylformylglycinamidine (or FGAM) is a biochemical intermediate in the formation of purine nucleotides via inosine-5-monophosphate, and hence is a building block for DNA and RNA.[1][2] The vitamins thiamine[3][4] and cobalamin[5] also contain fragments derived from FGAM.[6]
The compound is biosynthesized from phosphoribosyl-N-formylglycineamide (FGAR) which is converted to an amidine by the action of phosphoribosylformylglycinamidine synthase (Шаблон:EC number), transferring an amino group from glutamine in a reaction that also requires ATP:
- FGAR + ATP + glutamine + H2O → FGAM + ADP + glutamate + Pi
The biosynthesis pathway next converts FGAM to 5-aminoimidazole ribotide (AIR) by the action of AIR synthetase (Шаблон:EC number) which uses ATP to activate the terminal carbonyl group to attack by the nitrogen atom at the anomeric center:
- FGAM + ATP → AIR + ADP + Pi + H+
- Файл:AIR Synthetase.svg
See also
References
Шаблон:Nucleotide metabolism intermediates
