Английская Википедия:A-77636

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Версия от 18:16, 26 декабря 2023; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Chembox | Verifiedfields = changed | Watchedfields = changed | verifiedrevid = 477363088 | ImageFile = A-77636.svg | ImageFile_Ref = {{chemboximage|correct|??}} | ImageName = Stereo, Kekulé skeletal formula of A-77636 | PIN = (1''R'',3''S'')-3-(Adamantan-1-yl)-1-(aminomethyl)-1''H''-2-benzopyran-5,6-diol | Section1 = {{Chembox Identifiers | CASNo = 778546-51-3 | CASNo_Ref = {{cas...»)
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A-77636 is a synthetic drug which acts as a selective D1 receptor full agonist.[1] It has nootropic, anorectic, rewarding and antiparkinsonian effects in animal studies,[2][3][4][5][6] but its high potency and long duration of action causes D1 receptor downregulation and tachyphylaxis,[7][8][9] and unlike other D1 full agonists such as SKF-82,958, it does not produce place preference in animals.[10] A-77636 partially substituted for cocaine in animal studies, and has been suggested for use as a possible substitute drug in treating addiction,[11] but it is better known for its use in studying the role of D1 receptors in the brain.[12][13][14]

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