Английская Википедия:ADAMTS8

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Версия от 00:13, 27 декабря 2023; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''A disintegrin and metalloproteinase with thrombospondin motifs 8''' is an enzyme that in humans is encoded by the ''ADAMTS8'' gene.<ref name="pmid10438512">{{cite journal | vauthors = Vazquez F, Hastings G, Ortega MA, Lane TF, Oikemus S, Lombardo M, Iruela-Arispe ML | title = METH-1, a hum...»)
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Шаблон:Short description Шаблон:Infobox gene A disintegrin and metalloproteinase with thrombospondin motifs 8 is an enzyme that in humans is encoded by the ADAMTS8 gene.[1][2]

Function

This gene encodes a member of the ADAMTS (a disintegrin and metalloproteinase with thrombospondin motifs) protein family. Members of the family share several distinct protein modules, including a propeptide region, a metalloproteinase domain, a disintegrin-like domain, and a thrombospondin type 1 (TS) motif. Individual members of this family differ in the number of C-terminal TS motifs, and some have unique C-terminal domains. The enzyme encoded by this gene contains two C-terminal TS motifs, and disrupts angiogenesis in vivo.[2]

Clinical significance

A number of disorders have been mapped in the vicinity of this gene, most notably lung neoplasms.[2]

References

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Further reading

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External links

Шаблон:NLM content Шаблон:Metalloproteinases


Шаблон:Enzyme-stub

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  1. ↑ Шаблон:Cite journal
  2. ↑ 2,0 2,1 2,2 Шаблон:Cite web
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