Английская Википедия:ADK (gene)

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Версия от 00:19, 27 декабря 2023; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Adenosine kinase''' is an enzyme that in humans is encoded by the ''ADK'' gene.<ref name="pmid8577746">{{cite journal | vauthors = Spychala J, Datta NS, Takabayashi K, Datta M, Fox IH, Gribbin T, Mitchell BS | title = Cloning of human adenosine kinase cDNA: sequence similarity to microbial...»)
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Шаблон:Short description Шаблон:Infobox gene Adenosine kinase is an enzyme that in humans is encoded by the ADK gene.[1][2]

Function

This gene encodes adenosine kinase, an abundant enzyme in mammalian tissues. The enzyme catalyzes the transfer of the gamma-phosphate from ATP to adenosine, thereby serving as a regulator of concentrations of both extracellular adenosine and intracellular adenine nucleotides. Adenosine has widespread effects on the cardiovascular, nervous, respiratory, and immune systems and inhibitors of the enzyme could play an important pharmacological role in increasing intravascular adenosine concentrations and acting as anti-inflammatory agents. Alternative splicing results in two transcript variants encoding different isoforms. Both isoforms of the enzyme phosphorylate adenosine with identical kinetics and both require Mg2+ for activity.[2]

References

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External links

Further reading

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Шаблон:PDB Gallery Шаблон:Kinases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:2.7-enzyme-stub Шаблон:Gene-10-stub

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  1. ↑ Шаблон:Cite journal
  2. ↑ 2,0 2,1 Шаблон:Cite web
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