Английская Википедия:ARF6

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Версия от 05:21, 27 декабря 2023; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} <!--The PBB_Summary template is automatically maintained by Protein Box Bot. See Template:PBB_Controls to Stop updates.--> <!--{{PBB|geneid=382}}--> '''ADP-ribosylation factor 6''' ('''ARF6''') is a member of the ADP ribosylation factor family of GTP-binding proteins....»)
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Шаблон:Short description Шаблон:Infobox gene

ADP-ribosylation factor 6 (ARF6) is a member of the ADP ribosylation factor family of GTP-binding proteins. ARF6 has a variety of cellular functions that are frequently involved in trafficking of biological membranes and transmembrane protein cargo. ARF6 has specifically been implicated in endocytosis of plasma membrane proteins and also, to a lesser extent, plasma membrane protein recycling.

Function

This gene encodes a member of the human ARF gene family, which is part of the Ras superfamily. The ARF genes encode small guanine nucleotide-binding proteins that stimulate the ADP-ribosyltransferase activity of cholera toxin and play a role in vesicular trafficking and as activators of phospholipase D. The product of this gene is localized to the plasma membrane, and regulates vesicular trafficking, remodelling of membrane lipids, and signaling pathways that lead to actin remodeling. A pseudogene of this gene is located on chromosome 7.[1]

ARF6 can interact with βarrestin upon receptor activation.

Interactions

ARF6 has been shown to interact with:

References

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Further reading

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External links

Шаблон:PDB Gallery

Шаблон:GTPases