Английская Википедия:Activated protein C–protein C inhibitor

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Версия от 21:39, 30 декабря 2023; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} '''Activated protein C–protein C inhibitor''' ('''APC-PCI''') is a complex of activated protein C (APC) and protein C inhibitor (PCI).<ref name="pmid10608009">{{cite journal | vauthors = Merlini PA, Ardissino D | title = Laboratory Measurement of Thrombin Activity--What Every Clinician Scientist Needs to Know | journal = J Thromb Thrombolysis | volume = 2 | issue = 2 | pages...»)
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Activated protein C–protein C inhibitor (APC-PCI) is a complex of activated protein C (APC) and protein C inhibitor (PCI).[1][2][3] It has been measured in coagulation testing to evaluate coagulation, thrombosis, and other cardiovascular complications.[2][3][4] It is a marker of thrombin generation and indicates hypercoagulability.[1][5] The half-life of APC-PCI is either 40 minutes or 140Шаблон:Nbspminutes.[1]

Ethinylestradiol-containing birth control pills have been found to increase levels of APC-PCI to a similar degree as thrombin–antithrombin complex (TAT) and to a greater extent than D-dimer.[5] However, only APC-PCI was able to differentiate between a second- and third-generation birth control pill.[5]

Another complex related to APC-PCI is the activated protein C–α1-antitrypsin (APCAT) complex.[1]

References

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Шаблон:Coagulation Шаблон:Hematology blood tests


Шаблон:Biochemistry-stub Шаблон:Hematology-stub

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  1. ↑ 1,0 1,1 1,2 1,3 Шаблон:Cite journal
  2. ↑ 2,0 2,1 Шаблон:Cite journal
  3. ↑ 3,0 3,1 Шаблон:Cite journal
  4. ↑ Шаблон:Cite journal
  5. ↑ 5,0 5,1 5,2 Шаблон:Cite journal
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