Английская Википедия:Adiposogenital dystrophy
Шаблон:Infobox medical condition (new)
Adiposogenital dystrophy is a condition that may be caused by tertiary hypogonadism originating from decreased levels in GnRH. Low levels of GnRH has been associated with defects of the feeding centers of the hypothalamusШаблон:Citation needed, leading to an increased consumption of food and thus caloric intake.
Presentation
It is characterized by:Шаблон:Citation needed
- Obesity
- Growth delays and delayed sexual development, atrophy or hypoplasia of the gonads, and altered secondary sex characteristics,
- Headaches
- Problems with vision
- polyuria, polydipsia.
It is usually associated with tumors of the hypothalamus, causing increased appetite and depressed secretion of gonadotropin. It seems to affect males mostly.Шаблон:Citation neededMany overweight children may appear to have the disorder because of the concurrence of obesity and retarded sexual development; these children have no endocrine disturbances, however, and they mature normally after delayed puberty.Шаблон:Citation needed
Diagnosis
Laboratory analysis of the urine from children with Froehlich syndrome typically reveals low levels of pituitary hormones, and that finding may suggest the presence of a lesion on the pituitary. Additional tests are needed before a definite diagnosis of Froehlich syndrome may be made.[1]
Treatment
Pituitary extracts may be administered to replace the missing hormones (hormonal replacement therapy) in patients with Froehlich syndrome. Tumors of the hypothalamus should be surgically removed if possible. Appetite may be very difficult to manage, although weight control depends on this.Шаблон:Citation needed
References
External links
Шаблон:Medical resources Шаблон:Hypothalamic disease