Английская Википедия:Alinidine

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Alinidine (ST567) is a negative chronotrope that was developed in the 1970s and 1980s. It causes bradycardia by inhibiting the pacemaker current by altering the maximal channel conductance and alter the voltage threshold.[1] The development of alinidine was halted because it was not sufficiently specific for its target. It also has a blocking effect on calcium channels and potassium channels. It also causes elongation of re-polarisation after an action potential.[2]

Alinidine did not improve outcomes among patients with acute myocardial infarction in a randomized controlled trial.[3]

References

Шаблон:Reflist

Шаблон:Antihypertensives Шаблон:Calcium channel blockers Шаблон:Potassium channel blockers

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  1. ↑ Snyders DJ, Van Bogaert P-P: Alinidine modifies the pacemaker current in sheep Purkinje fibers. Pflügers Arch 1987, 410:83-91
  2. ↑ Current Opinion in Pharmacology 2007, 7:208–213
  3. ↑ Шаблон:Cite journal
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