Английская Википедия:Amixetrine

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Шаблон:Short description Шаблон:Drugbox

Amixetrine (INN) (brand name Somagest; developmental code name CERM-898) is a drug that was formerly marketed in France but is now no longer sold.[1][2] According to various sources it has been said to be an anti-inflammatory, antidepressant, antispasmodic, anticholinergic, antihistamine, and antiserotonergic, but its definitive indications and pharmacology are unclear.[1][2] The drug was first synthesized in 1969 and was introduced in France in 1972.[1][2]

Synthesis

Файл:Amixetrine synthesis.svg
Patent:[3] Reagent:[4]

The treatment of isoamyl alcohol (1) with styrene (2) at -10°C with dropwise addition of tert-Butyl Hypobromite [1611-82-1] gives (2-bromo-1-(isopentyloxy)ethyl)benzene [5452-50-6] (3). Displacement of the halogen leaving group by pyrrolidine completes the synthesis of amixetrine (4).

References

Шаблон:Reflist


Шаблон:Musculoskeletal-drug-stub

Партнерские ресурсы
Криптовалюты
Магазины
Хостинг
Разное

  1. ↑ 1,0 1,1 1,2 Шаблон:Cite book
  2. ↑ 2,0 2,1 2,2 Шаблон:Cite book
  3. ↑ Шаблон:Cite patent idem Mauvernay Roland Yves, Norbert Busch, DE1811767A1 (1969 to Ct Europ De Rech S Mauvernay).
  4. ↑ Finkelstein, B. L., Hu, T. (15 March 2009). "Encyclopedia of Reagents for Organic Synthesis". In John Wiley & Sons, Ltd (eds.). tert -Butyl Hypobromite. John Wiley & Sons, Ltd. pp. rb387.pub2. doi:10.1002/047084289X.rb387.pub2.
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