Английская Википедия:Ardisiaquinone
Шаблон:Chembox Ardisiaquinones are a group of closely related chemical compounds found in plants in the genus Ardisia. The first examples, ardisiaquinones A-C, were isolated in 1968 from Ardisia sieboldii.[1] In 1995, ardisiaquinones D, E, and F were discovered, also from Ardisia sieboldii.[2] In 2001, ardisiaquinones G, H and I were isolated from Ardisia teysmanniana.[3]
Chemically, the ardisiaquinones consist of two variably-substituted 1,4-benzoquinone units connected by a long alkyl or alkenyl chain.[1]
Research
Ardisiaquinones are of research interest because they possess 5-lipoxygenase (5-LOX) inhibitor activity and 5-LOX has clinical relevance in inflammation.[4] For example, ardisiaquinone A protects against liver injury in an animal model of ischemia-reperfusion injury.[5] Likewise, ardisiaquinone G has also shown 5-LOX inhibition.[4] Ardisiaquinone A has also been shown to have an antiallergic effect in an animal model.[6] Other ardisiaquinones have shown antiproliferative and antimicrobial effects in vitro.[7]
Laboratory syntheses of ardisiaquinones A and B have been reported.[8][9]
Chemical structures
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Ardisiaquinone A
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Ardisiaquinone B
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Ardisiaquinone C
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Ardisiaquinone D
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Ardisiaquinone E
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Ardisiaquinone F
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Ardisiaquinone G
References
