Английская Википедия:Arrestin beta 1

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Версия от 22:28, 2 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Human protein and coding gene}} {{Infobox_gene}} '''Arrestin, beta 1''', also known as '''ARRB1''', is a protein which in humans is encoded by the ''ARRB1'' gene.<ref name="pmid8486659">{{cite journal | vauthors = Parruti G, Peracchia F, Sallese M, Ambrosini G, Masini M, Rotilio D, De Blasi A | title = Molecular analysis of human beta-arrestin-1: cloning, ti...»)
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Шаблон:Short description Шаблон:Infobox gene Arrestin, beta 1, also known as ARRB1, is a protein which in humans is encoded by the ARRB1 gene.[1][2]

Function

Members of arrestin/beta-arrestin protein family are thought to participate in agonist-mediated desensitization of G protein-coupled receptors and cause specific dampening of cellular responses to stimuli such as hormones, neurotransmitters, or sensory signals. Arrestin beta 1 is a cytosolic protein and acts as a cofactor in the beta-adrenergic receptor kinase (BARK) mediated desensitization of beta-adrenergic receptors. Besides the central nervous system, it is expressed at high levels in peripheral blood leukocytes, and thus the BARK/beta-arrestin system is believed to play a major role in regulating receptor-mediated immune functions. Alternatively spliced transcripts encoding different isoforms of arrestin beta 1 have been described, however, their exact functions are not known.[2] Beta-arrestin has been shown to play a role as a scaffold that binds intermediates and may direct G-protein signaling by connecting receptors to clathrin-mediated endocytosis.[3]

Interactions

Arrestin beta 1 has been shown to interact with

References

Шаблон:Reflist

Further reading

Шаблон:Refbegin

Шаблон:Refend

External links

Шаблон:PDB Gallery Шаблон:Membrane proteins

Партнерские ресурсы
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Разное

  1. ↑ Шаблон:Cite journal
  2. ↑ 2,0 2,1 Шаблон:Cite web
  3. ↑ Шаблон:Cite journal
  4. ↑ 4,0 4,1 Шаблон:Cite journal
  5. ↑ Шаблон:Cite journal
  6. ↑ Шаблон:Cite journal
  7. ↑ Шаблон:Cite journal
  8. ↑ Шаблон:Cite journal
  9. ↑ Шаблон:Cite journal
  10. ↑ Шаблон:Cite journal
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