Английская Википедия:Artesunate/pyronaridine
Шаблон:Short description Шаблон:Drugbox Artesunate/pyronaridine, sold under the brand name Pyramax, is a fixed-dose combination medication for the treatment of malaria.[1][2] It can be used for malaria of both the P. falciparum and P. vivax types.[2] It combines artesunate and pyronaridine.[1] It is taken by mouth.[3]
The combination is generally well tolerated.[2] Side effects may include headache, vomiting, or cough.[2] Use in those with severe liver disease or kidney disease is not recommended.[3] Use is not generally recommended in early pregnancy.[3] However, there are no other options and if treatment may save the mother's life it may be used.[3] The two components work by different mechanisms.[3]
It is on the World Health Organization's List of Essential Medicines.[1]
Medical uses
Artesunate/pyronaridine is used for malaria of both the P. falciparum and P. vivax types.[2] It is not recommended for severe disease.[3]
A 2019 review (updated in 2021) found that the combination compared well to artemether/lumefantrine.[4] Benefits also appear similar to mefloquine together with artesunate.[4] It is not recommended for the prevention of malaria.[3]
Research for drug repurposing
There is some in vitro evidence that suggests artesunate/pyronaridine may be worthy of clinical trial study to determine whether it might have a role as a drug for COVID-19 treatment.[5]
References
