Английская Википедия:Astemizole
Шаблон:Short description Шаблон:Drugbox
Astemizole (marketed under the brand name Hismanal, developmental code R43512) was a second-generation antihistamine drug that has a long duration of action. Astemizole was discovered by Janssen Pharmaceutica in 1977. It was withdrawn from the market globally in 1999 because of rare but potentially fatal side effects (QTc interval prolongation and related arrhythmias due to hERG channel blockade).[1][2]
Pharmacology
Astemizole is a histamine H1-receptor antagonist. It has anticholinergic and antipruritic effects.
Astemizole is rapidly absorbed from the gastrointestinal tract and competitively binds to histamine H1 receptor sites in the gastrointestinal tract, uterus, blood vessels, and bronchial muscle. This suppresses the formation of edema and pruritus (caused by histamine).
Despite some earlier reports that astemizole does not cross the blood–brain barrier, several studies[3][4] have shown high permeability and high binding to protein folds associated with Alzheimer's.
Astemizole may also act on histamine H3 receptors, thereby producing adverse effects.Шаблон:Citation needed
Astemizole does also act as FIASMA (functional inhibitor of acid sphingomyelinase).[5]
Astemizole has been researched as a treatment for Creutzfeldt-Jakob Disease (CJD).[6]
Toxicity
Astemizole has an oral LD50 of approximately 2052 mg/kg (in mice).
References
External links
Шаблон:Antihistamines Шаблон:Cholinergics Шаблон:Histaminergics
- Английская Википедия
- Phenethylamines
- Belgian inventions
- Benzimidazoles
- Fluoroarenes
- H1 receptor antagonists
- HERG blocker
- Janssen Pharmaceutica
- Phenol ethers
- Piperidines
- Withdrawn drugs
- Страницы, где используется шаблон "Навигационная таблица/Телепорт"
- Страницы с телепортом
- Википедия
- Статья из Википедии
- Статья из Английской Википедии
