Английская Википедия:BAG1

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Версия от 22:51, 4 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''BAG family molecular chaperone regulator 1''' is a protein that in humans is encoded by the ''BAG1'' gene.<ref name="pmid7834747">{{cite journal | vauthors = Takayama S, Sato T, Krajewski S, Kochel K, Irie S, Millan JA, Reed JC | title = Cloning and functional analysis of BAG-1: a novel Bc...»)
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Шаблон:Short description Шаблон:Infobox gene BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.[1]

Function

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.[2]

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.[3]

Interactions

BAG1 has been shown to interact with: Шаблон:Div col

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References

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External links

Further reading

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