Английская Википедия:BAZ1A

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Версия от 23:04, 4 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} '''Bromodomain adjacent to zinc finger domain protein 1A''' is a protein that in humans is encoded by the ''BAZ1A'' gene.<ref name="pmid10662543">{{cite journal |vauthors=Jones MH, Hamana N, Nezu J, Shimane M | title = A novel family of bromodomain genes | journal = Genomics | volume = 63 | issue = 1 | pages...»)
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Шаблон:Short description Bromodomain adjacent to zinc finger domain protein 1A is a protein that in humans is encoded by the BAZ1A gene.[1][2]

Structure

The protein encoded by this gene belongs to a family of proteins which includes BAZ1B, BAZ2A, and BAZ2B. All family members contain the following domains and structural motifs:[1]

Function

BAZ1A along with SMARCA5, POLE3, and CHRAC1 comprise the WCRF/CHRAC ATP-dependent chromatin-remodeling complex.[3][4]

The purified CHRAC complex can mobilize nucleosomes into a regularly spaced nucleosomal array, and the spacing activity is ATP-dependent.[4] Furthermore, the BAZ1A-SMARCA5 complex enables DNA replication through highly condensed regions of chromatin.[5]

Interactions

BAZ1A has been shown to interact with SMARCA5[3][4][6][7][8] and SATB1.[7]

References

Шаблон:Reflist


Шаблон:Gene-14-stub