Английская Википедия:BDS-1

Материал из Онлайн справочника
Версия от 00:14, 5 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Infobox |name = BDS-1 |bodystyle = |titlestyle = |abovestyle = background:#cfc; |subheaderstyle = |title = Infobox |above = BDS-1 |imagestyle = |captionstyle = | image = |caption = |headerstyle = background:#ccf; |labelstyle = background:#ddf; |datastyle = |header1 = Identifiers | label1 = | data1 = |header2 =...»)
(разн.) ← Предыдущая версия | Текущая версия (разн.) | Следующая версия → (разн.)
Перейти к навигацииПерейти к поиску

Шаблон:Infobox

Blood-depressing substance-1 (BDS-1), also known as kappa-actitoxin-Avd4a, is a polypeptide found in the venom of the snakelocks anemone Anemonia sulcata.[1] BDS-1 is a neurotoxin that modulates voltage-dependent potassium channels, in particular Kv3-family channels, as well as certain sodium channels.[2][3] This polypeptide belongs to the sea anemone type 3 toxin peptide family.[1]

Etymology

BDS-1 brings about a decrease in blood pressure by blocking Kv3 potassium channels. Thus, this protein is named after its antihypertensive function.[4]

Sources

BDS-1 is a toxin secreted by the nematocyst of Anemonia sulcata (Mediterranean snakelocks sea anemone).[1]

Chemistry

BDS-1 is a 43 amino acids long polypeptide chain, which consists of six cysteines linked by three disulfide bridges. The secondary structure of BDS-1 possesses three-stranded antiparallel β-sheets, along with one more short antiparallel β-sheet at its N-terminus.[5][6] When viewed along the polypeptide strand, its structure showa a right-handed twist.[6]

BDS-1 shares structural homology with the toxin BDS-2, which belongs to the same type-3 peptide family. It also displays around 24–26% identity with toxins AsI (ATX-I), AsII (ATX-II), and AsV (ATX-V) from Anemonia sulcata and AxI (AP-A) from Anthopleura xanthogrammica.[4]

Target

BDS-1 is an inhibitor of the fast inactivating Kv3-family channels, including Kv3.1, Kv3.2 and Kv3.4 channels.[2] Additionally, BDS-1 affects the inactivation of voltage-gated sodium channels, Nav1.1, Nav1.3, Nav1.6 and Nav1.7.[3]

Mode of action

BDS-1 modifies the voltage-dependent gating properties of Kv3 potassium channels by binding to the voltage sensitive domains on S3b and S4 subunits.[2] The toxin elicits a depolarizing shift in the conductance-voltage relation, making it more difficult to open, and slows both the activation and inactivation kinetics of these ion channels.[2]

In addition, BDS-1 enhances the current flowing through several voltage-gated sodium channels. The toxin binds to the S3-S4 linker of domain IV and slows the inactivation of the channel, resulting in increased current upon depolarization. BDS-1 has a very strong potency for the human Nav1.7 channel. In mice, BDS-1 slows the inactivation of Nav1.3 channels but has smaller effects on the inactivation of Nav1.1 and Nav1.6 channels. This is probably due to a different channel sensitivity for the toxin.[3]

Toxicity

By targeting Kv3.1a channels, BDS-1 concentrations at or above 3 μM are toxic to mouse fibroblasts.[2]

References

Шаблон:Reflist

Партнерские ресурсы
Криптовалюты
Магазины
Хостинг
Разное

  1. ↑ 1,0 1,1 1,2 Шаблон:Cite web
  2. ↑ 2,0 2,1 2,2 2,3 2,4 Шаблон:Cite journal
  3. ↑ 3,0 3,1 3,2 Шаблон:Cite journal
  4. ↑ 4,0 4,1 Шаблон:Cite journal
  5. ↑ Шаблон:Cite journal
  6. ↑ 6,0 6,1 Шаблон:Cite journal
Источник — http://wikihandbk.com/ruwiki/index.php?title=Английская_Википедия:BDS-1&oldid=13349083