Английская Википедия:Bicifadine

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Шаблон:Short description Шаблон:Drugbox

Bicifadine (DOV-220,075) is a serotonin-norepinephrine-dopamine reuptake inhibitor (SNDRI) discovered at American Cyanamid as an analgesic drug candidate, and licensed to DOV Pharmaceutical in 1998 after American Cyanamid was acquired by Wyeth.[1][2][3]

In January 2007, Dov licensed the rights to bicifadine to XTL Biopharmaceuticals after bicifadine failed in a Phase III clinical trial for chronic lower back pain.[4][5][6] XTL ran a PhaseIIb clinical trial for pain caused by diabetic neuropathy, which failed in 2008;[7] XTL terminated the agreement in 2010.[8] In 2010 Dov was acquired by Euthymics Bioscience which intended to continue development of other candidates from Dov's portfolio.[9]

Bicifadine has a non-opioid, non-NSAID mechanism for the treatment of pain, which should have less abuse potential than opioid drugs and less propensity to cause gastric ulcers than NSAID drugs.[10] While the drug is purported to be a serotonin (SERT) and noradrenaline transporter (NET) inhibitor, it also has effects at the dopamine transporter (DAT), effectively making it a broad-spectrum monoamine transporter inhibitor or "triple reuptake inhibitor."[11]

See also

References

Шаблон:Reflist

Шаблон:Analgesics Шаблон:Antidepressants Шаблон:Monoamine reuptake inhibitors

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  1. ↑ Шаблон:Cite journal
  2. ↑ SEC Filing: Wyeth-DOV Restated License Agreement Page accessed July 15, 2015]
  3. ↑ Шаблон:Cite book
  4. ↑ Шаблон:Cite web
  5. ↑ Шаблон:Cite web
  6. ↑ Шаблон:Cite web
  7. ↑ Fierce Biotech. December 9, 2008 Tiny XTL cuts costs, jobs
  8. ↑ Шаблон:Cite web
  9. ↑ Fierce Biotech July 22, 2010 Euthymics lands $24M to fund antidepressant work
  10. ↑ Шаблон:Cite journal
  11. ↑ Шаблон:Cite journal
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