Английская Википедия:Bundaberg tragedy
The Bundaberg tragedy (or Bundaberg disaster) was a medical disaster that occurred in January 1928, resulting in the deaths of 12 children in Bundaberg, Queensland, Australia. A royal commission concluded that the deaths were caused by the contamination of a diphtheria vaccine with the bacterium Staphylococcus aureus.
Background
The Australian state of Queensland experienced frequent diphtheria outbreaks in the early 20th century, with up to 2,000 cases reported per annum.Шаблон:Sfn In the city of Bundaberg there were 130 cases reported in 1926 and 89 cases in 1927.Шаблон:Sfn The disease had a high mortality rate and in a number of years was the leading cause of childhood death in Australia.Шаблон:Sfn
The federal government recommended immunisation against diphtheria as early as 1921, but uptake of the diphtheria vaccine was slow.Шаблон:Sfn Some medical authorities felt that the effectiveness of mass immunisation had yet to be proven, while the decentralised nature of the Australian healthcare system meant that decisions on immunisation were made by local health boards and medical officers of health.Шаблон:Sfn
By the late 1920s, the Queensland Department of Health had initiated a policy of free immunisation against diphtheria, with the department purchasing vaccines manufactured by the federal government's Commonwealth Serum Laboratories (CSL) and distributing them to local authorities.Шаблон:Sfn In 1928, the joint health board covering the City of Bundaberg, the Shire of Woongarra and the Shire of Gooburrum voted to authorise an immunisation program. The scheme was to be led by Bundaberg's chief medical officer Ewing Thomson.Шаблон:Sfn
Disaster
Thomson began the immunisation program on 17 January 1928, with each recipient intended to receive three inoculations spaced one week part.Шаблон:Sfn The program was without incident until 27 January, when a total of 21 children between the ages of one and nine were inoculated.Шаблон:Sfn Within seven hours, 18 of the children were seriously ill with symptoms that began with vomiting and diarrhoea and progressed to fever, cyanosis, convulsions and unconsciousness.Шаблон:Sfn Eleven children died within 24 hours of their inoculations, while another died on the following day; many died only hours after being admitted to hospital.Шаблон:Sfn Three were from a single family, the Robinsons,Шаблон:Sfn while two other families lost two children. Thomson's son was among those inoculated, but survived.Шаблон:Sfn
The mass-casualty incident overwhelmed the town's two hospitals, Bundaberg General Hospital and St Vincent's Hospital, which did not have the staff or capacity to handle multiple paediatric emergencies.Шаблон:Sfn The hospitals' mortuary facilities were also inadequate to deal with multiple victims, with the problem exacerbated by an ongoing heat wave. With one exception, post-mortem examinations were performed by Egmont Schmidt, the government medical officer of Maryborough, who concluded that the children had died due to "acute toxaemia" of an unknown cause. Schmidt had little experience in forensic analysis, also lacking access to expert advice and facing pressure from families to certify death so that interment could proceed.Шаблон:Sfn
Reaction and investigation
Health response
The inoculation program in Bundaberg was suspended immediately after the children's deaths, following shortly by those in the major cities of Brisbane and Melbourne. As news of the deaths spread, programs were also suspended in New Zealand and Cape Town, South Africa.Шаблон:Sfn All bottles of the toxin-antitoxin (TAT) serum used in Bundaberg were recalled within two days.Шаблон:Sfn However, it was soon discovered that the Bundaberg batch had been used in other locations without incident. An early consensus developed that the deaths had not been caused by a fault in manufacture, but rather by the treatment of the serum after it left the CSL facilities in Melbourne.Шаблон:Sfn
Political response
On 31 January, the day of the last victim's funeral, Prime Minister S. M. Bruce announced a royal commission into the deaths.Шаблон:Sfn He additionally sent federal treasurer Earle Page, a former surgeon, to Bundaberg as his personal representative.Шаблон:Sfn The federal government's response was coordinated by John Cumpston, the director-general of the Department of Health, a strong supporter of mass immunisation who sought to defend the reputation of his department and CSL.Шаблон:Sfn According to Akers & Porter (2008), "the swift announcement of an imminent Royal Commission, its open terms of reference and Page's visit, engendered scientific and political confidence".Шаблон:Sfn
Royal commission
The federal government called a royal commission into the deaths on 31 January, the day of the last victim's funeral.Шаблон:Sfn Hearings began on 13 February.Шаблон:Sfn The manufacturer of the toxin–antitoxin was Commonwealth Serum Laboratories (CSL), owned by the federal government. As a result, responsibility for the deaths was seen to lie with the federal government rather than the Queensland state government (the administrators of the immunisation program), and inquiries were conducted by the federal government.
The three commissioners were Charles Kellaway, director of the Walter and Eliza Hall Institute; Peter MacCallum, professor of pathology at the University of Melbourne; and Arthur Tebbutt, bacteriologist at Sydney's Royal Prince Alfred Hospital. Kellaway was appointed as the commission's chairman. There was some criticism of the appointment of three medical professionals. The commissioners heard evidence in Bundaberg, Stanthorpe, Toowoomba, Brisbane, Sydney, and Melbourne. The sessions were open to the press and were extensively reported. Kellaway delegated much of the commission's work to Macfarlane Burnet, his assistant director at the Hall Institute and a future Nobel Prize laureate. Burnet was able to isolate Staphylococcus aureus in both the toxin-antitoxin mixture and in pus taken from the surviving children.Шаблон:Sfn
The commission's report was presented to the House of Representatives by Neville Howse on 13 June 1928. There was a four-month investigation.Шаблон:Sfn The Medical Journal of Australia and British Medical Journal concurred with the findings of the commission.Шаблон:Sfn The commission concluded that the children's deaths were the result of the serum being contaminated with the bacterium Staphylococcus aureus. The commission concluded that the manufacturer, CSL, had contributed to the deaths by distributing bottles of serum that did not contain antiseptic.Шаблон:Sfn
The report made five main recommendations. It was immediately forwarded to the state departments of health. The day after the report was issued, Prime Minister Stanley Bruce announced that the federal government would issued compensation payments to the families of the deceased and would cover the medical expenses of the surviving children.Шаблон:Sfn
See also
- 1901 diphtheria antitoxin contamination incident, a similar incident in the United States
References
Sources
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