Английская Википедия:Butamirate
Шаблон:Short description Шаблон:Drugbox Butamirate (or brospamin, trade names Acodeen, Codesin, Pertix, Sinecod, Sinecoden, Sinecodix) is a cough suppressant.[1] It has been marketed in Europe and Mexico, but not in the United States.[2]
It is sold in the form of lozenges, syrup, tablets, dragées, or pastilles as the citrate salt. Adverse effects can include nausea, diarrhea, vertigo, and exanthema.[2]
Pharmacology
A study found it to bind to the cough center in the medulla oblongata, more specifically the dextromethorphan-binding site in guinea pig brain with high affinity.[3]
As a 2-(2-diethylaminoethoxy)ethyl ester, it is chemically related to oxeladin and pentoxyverine, which are in the same class. (Oxeladin has an additional ethyl group in its carboxylic acid, pentoxyverine has both ethyl groups of oxeladin replaced by one cyclopentyl in the same place.)
See also
- Cough syrup
- Noscapine
- Codeine; Pholcodine
- Dextromethorphan; Dimemorfan
- Racemorphan; Dextrorphan; Levorphanol
- Pentoxyverine
- Tipepidine
- Cloperastine; Levocloperastine
References
Шаблон:Cough and cold preparations
Шаблон:Respiratory-system-drug-stub
