Английская Википедия:CDC37
Шаблон:Short description Шаблон:Infobox gene Шаблон:Infobox protein family Шаблон:Infobox protein family Шаблон:Infobox protein family Hsp90 co-chaperone Cdc37 is a protein that in humans is encoded by the CDC37 gene.[1] This protein is highly similar to Cdc 37, a cell division cycle control protein of Saccharomyces cerevisiae. This protein is a HSP90 Co-chaperone[2] with specific function in cell signal transduction. It has been shown to form complex with Hsp90 and a variety of protein kinases including CDK4, CDK6, SRC, RAF1, MOK, as well as eIF-2 alpha kinases. It is thought to play a critical role in directing Hsp90 to its target kinases.[3]
Interactions
CDC37 has been shown to interact with: Шаблон:Div col
Domain architecture
CDC37 consists of three structural domains. The N-terminal domain binds to protein kinases.[12] The central domain is the Hsp90 chaperone (heat shock protein 90) binding domain.[13] The function of the C-terminal domain is unclear.
References
Further reading
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External links