Английская Википедия:CHEB
Шаблон:Chembox CHEB, also known as BRN 0250312 is a convulsant barbiturate. Its mechanism of action is not fully understood.
Pharmacodynamics
CHEB has uncommon action compared to other barbiturates. While other barbiturates such as Barbital are usually anticonvulsants, CHEB is a convulsant.
CHEB's convulsant action is not fully understood. There may be multiple mechanisms involved in its properties;
In rats, CHEB stimulates the release of glutamate, an excitatory neurotransmitter.[1]
In low doses, CHEB can block the action of glycine, thus operating in a strychnine similar way.[2]
Another study has shown that CHEB could increase the release of acetylcholine. This result was not observed with some other convulsants (S(+)-MPPB, pentylenetetrazol and Ro-5-3663), suggesting that this property is unique.[3]
Paradoxically, CHEB is able to enhance the binding of GABA, this is a strange property, as compounds that enhance GABA binding usually have anticonvulsant action, such as Diazepam.[4]
References
