Английская Википедия:Cathepsin H

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Версия от 19:43, 15 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Protein-coding gene in the species Homo sapiens}} {{Infobox_gene}} '''Cathepsin H''' is a protein that in humans is encoded by the ''CTSH'' gene.<ref name="pmid2849458">{{cite journal | vauthors = Fuchs R, Machleidt W, Gassen HG | title = Molecular cloning and sequencing of a cDNA coding for mature human kidney cathepsin H | journal = Biol Chem Hoppe-Seyler...»)
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Шаблон:Short description Шаблон:Infobox gene Cathepsin H is a protein that in humans is encoded by the CTSH gene.[1][2]

The protein encoded by this gene is a cysteine cathepsin, a lysosomal cysteine protease important in the overall degradation of lysosomal proteins. It is composed of a dimer of disulfide-linked heavy and light chains, both produced from a single protein precursor. The encoded protein, which belongs to the peptidase C1 protein family, can act both as an aminopeptidase and as an endopeptidase. Increased expression of this gene has been correlated with malignant progression of prostate tumors. Two transcript variants encoding different isoforms have been found for this gene.[2]

References

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Further reading

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External links

  • The MEROPS online database for peptidases and their inhibitors: C01.040

Шаблон:PDB Gallery

Шаблон:Cysteine proteases Шаблон:Enzymes Шаблон:Portal bar


Шаблон:Gene-15-stub

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  1. ↑ Шаблон:Cite journal
  2. ↑ 2,0 2,1 Шаблон:Cite web
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