Английская Википедия:Chalcone isomerase
Шаблон:Infobox enzyme Шаблон:Infobox protein family In enzymology, a chalcone isomerase (Шаблон:EnzExplorer) is an enzyme that catalyzes the chemical reaction
- a chalcone <math>\rightleftharpoons</math> a flavanone
Hence, this enzyme has one substrate, a chalcone, and one product, a flavanone.
This enzyme belongs to the family of isomerases, specifically the class of intramolecular lyases. The systematic name of this enzyme class is flavanone lyase (decyclizing). This enzyme is also called chalcone-flavanone isomerase. This enzyme participates in flavonoid biosynthesis.
The Petunia hybrida (Petunia) genome contains two genes coding for very similar enzymes, ChiA and ChiB, but only the first seems to encode a functional chalcone isomerase.
Structural studies
As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, Шаблон:PDB link, and Шаблон:PDB link.
Chalcone isomerase has a core 2-layer alpha/beta structure consisting of beta(3)-alpha(2)-beta-alpha(2)-beta(3).[1]
References
Further reading
Шаблон:InterPro content Шаблон:Intramolecular Lyases Шаблон:Enzymes Шаблон:Portal bar
