Английская Википедия:Chromone
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Chromone (or 1,4-benzopyrone) is a derivative of benzopyran with a substituted keto group on the pyran ring. It is an isomer of coumarin.
Derivatives of chromone are collectively known as chromones. Most, though not all, chromones are also phenylpropanoids.
Examples
- 6,7-dimethoxy-2,3-dihydrochromone has been isolated from Sarcolobus globosus.
- Eucryphin, a chromone rhamnoside, can be isolated from the bark of Eucryphia cordifolia.[1]
- Cromolyn (disodium cromoglicate) was found to inhibit antigen challenge as well as stress induced symptoms.[2] Cromoglicate is used as a mast cell stabilizer in allergic rhinitis, asthma and allergic conjunctivitis.
- Nedocromil sodium was found to have a somewhat longer half-life than cromolyn; however, production was discontinued in the US in 2008.
- Xanthone with a second aromatic ring.
See also
- Coumarin – a structural isomer
- Furanochromones
References
- ↑ Eucryphin, a new chromone rhamnoside from the bark of Eucryphia cordifolia. R. Tschesche, S. Delhvi, S. Sepulveda and E. Breitmaier, Phytochemistry, Volume 18, Issue 5, 1979, pages 867–869, Шаблон:Doi
- ↑ HOWELL, J.B. & ALTOUNYAN, R.E. (1967). A double-blind trial of disodium cromoglycate in the treatment of allergic bronchial asthma. Lancet, 2, 539–542. Abstract
External links
- Шаблон:PubChem – "4-chromone"
- Шаблон:MeshName
- Synthesis at organic-chemistry.org
