Английская Википедия:Circoviridae

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Версия от 04:41, 19 февраля 2024; EducationBot (обсуждение | вклад) (Новая страница: «{{Английская Википедия/Панель перехода}} {{Short description|Family of viruses}} {{Use dmy dates|date=April 2017}} {{Virusbox | taxon = Circoviridae | subdivision_ranks = Genera | subdivision = * ''Circovirus'' * ''Cyclovirus'' }} '''''Circoviridae''''' is a family of DNA viruses.<ref>{{cite journal |doi=10.1099/jgv.0.000871 |pmid=28786778 |pmc=5656780 |title=ICTV Virus Taxonomy Profile: Circ...»)
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Шаблон:Short description Шаблон:Use dmy dates Шаблон:Virusbox

Circoviridae is a family of DNA viruses.[1][2] Birds and mammals serve as natural hosts. There are 101 species in this family, assigned to 2 genera. Diseases associated with this family include: PCV-2: postweaning multisystemic wasting syndrome; CAV: chicken infectious anemia.[3][4]

Structure

Viruses in the family Circoviridae are non-enveloped, with icosahedral and round geometries, and T=1 symmetry.[2] The diameter is around 20 nm. Genomes are circular and non-segmented, around 3.8kb in length. The capsid consists of 12 pentagonal trumpet-shaped pentamers.[3] There are two main open reading frames arranged in opposite directions that encode the replication and capsid proteins. Alternative start codons are common in the avian species.Шаблон:Citation needed

Genus Structure Symmetry Capsid Genomic arrangement Genomic segmentation
Cyclovirus Icosahedral T=1 Non-enveloped Circular Monopartite
Circovirus Icosahedral T=1 Non-enveloped Circular Monopartite

Life cycle

Viral replication is nuclear. Entry into the host cell is achieved by penetration into the host cell. Replication follows the ssDNA rolling circle model. DNA templated transcription, with some alternative splicing mechanism is the method of transcription. The virus exits the host cell by nuclear egress, and nuclear pore export.[2][3] A stem loop structure with a conserved nonanucleotide motif is located at the 5' intergenic region of circovirus genomes and is thought to initiate rolling-cycle replication. Birds and mammals serve as the natural host. Transmission routes are fecal-oral.[2][3]

Genus Host Tissue tropism Entry Release Replication site Assembly site Transmission
Cyclovirus Birds Chicken: Thymocytes, erythrobalstoid cells; Egg: embryonal tissues and eggshell membrane Cell receptor endocytosis Budding Nucleus Nucleus Horizontal: oral-fecal; vertical: bird to egg
Circovirus Birds; pigs None Cell receptor endocytosis Budding Nucleus Nucleus Horizontal; oral-fecal

Taxonomy

The family Circoviridae contains two genera—Circovirus and Cyclovirus.

Clinical

A cyclovirus—cyclovirus-Vietnam—has been isolated from the cerebrospinal fluid of 25 Vietnamese patients with CNS infections of unknown aetiology.[6] The same virus has been isolated from the faeces of healthy children and also from pigs and chickens. This suggests an orofaecal route of transmission with a possible animal reservoir.[6]

See also

References

Шаблон:Reflist

External links

Шаблон:Baltimore classification

Шаблон:Taxonbar Шаблон:Authority control

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  1. ↑ Шаблон:Cite journal
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 Шаблон:Cite web
  3. ↑ 3,0 3,1 3,2 3,3 Шаблон:Cite web
  4. ↑ Шаблон:Cite web
  5. ↑ Шаблон:Cite journal
  6. ↑ 6,0 6,1 Шаблон:Cite journal
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