Английская Википедия:Complete androgen insensitivity syndrome

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Шаблон:Short description Шаблон:Infobox medical condition (new)

Complete androgen insensitivity syndrome (CAIS) is an AIS condition that results in the complete inability of the cell to respond to androgens.[1][2][3] As such, the insensitivity to androgens is only clinically significant when it occurs in individuals who are exposed to significant amounts of testosterone at some point in their lives.[1] The unresponsiveness of the cell to the presence of androgenic hormones prevents the masculinization of male genitalia in the developing fetus, as well as the development of male secondary sexual characteristics at puberty, but does allow, without significant impairment, female genital and sexual development[3][4] in those with the condition.

All human fetuses begin fetal development looking similar, with both the Müllerian duct system (female) and the Wolffian duct system (male) developing. It is at the seventh week of gestation that the bodies of unaffected individuals with the XY karyotype begin their masculinization: i.e., the Wolffian duct system is promoted and the Müllerian duct system is suppressed (the reverse happens with typically developing females). This process is triggered by androgens produced by the gonads, which in individuals with the XX karyotype had earlier become ovaries, but in XY individuals typically had become testicles due to the presence of the Y chromosome. The cells of unaffected XY individuals then masculinize by, among other things, enlarging the genital tubercle into a penis, which in females becomes the clitoris, while what in females becomes the labia fuses to become the scrotum of males (where the testicles will later descend).

Individuals affected by CAIS develop a normal external female habitus, despite the presence of a Y chromosome,[1][5][6][7][8][9] but internally, they will lack a uterus, and the vaginal cavity will be shallow, while the gonads, having been turned into testicles rather than ovaries in the earlier separate process also triggered by their Y chromosome, will remain undescended in the place where the ovaries would have been. This results not only in infertility in individuals with CAIS, but also presents a risk of gonadal cancer later on in life.[10]

CAIS is one of the three categories of androgen insensitivity syndrome (AIS) since AIS is differentiated according to the degree of genital masculinization: complete androgen insensitivity syndrome (CAIS) when the external genitalia is that of a typical female, mild androgen insensitivity syndrome (MAIS) when the external genitalia is that of a typical male, and partial androgen insensitivity syndrome (PAIS) when the external genitalia is partially, but not fully masculinized.[1][2][5][6][7][11][12][13][14]

Androgen insensitivity syndrome is the largest single entity that leads to 46, XY undermasculinization.[15]

Signs and symptoms

Physical

Файл:Complete androgen insensitivity syndrome.jpg
Persons with a complete androgen insensitivity have a typical female external phenotype, despite having a 46,XY karyotype.[16][17]

Individuals with complete androgen insensitivity syndrome (grades 6 and 7 on the Quigley scale) are born phenotypically female, without any signs of genital masculinization, despite having a 46,XY karyotype.[18] Symptoms of CAIS do not appear until puberty,[2] which may be slightly delayed,[19] but is otherwise normal except for absent menses and diminished or absent secondary terminal hair.[1] Axillary hair (i.e. armpit hair) fails to develop in one third of all cases.[20] The vulva is normal, although the labia and clitoris are sometimes underdeveloped.[21][22] Vaginal depth varies widely for CAIS women, but is typically shorter than unaffected women;[1] one study of eight women with CAIS measured the average vaginal depth to be 5.9 cm [23] (vs. 11.1 ± 1.0 cm for unaffected women [24]). In some extreme cases, the vagina has been reported to be aplastic (resembling a "dimple"), though the exact incidence of this is unknown.[25]

The gonads in these women are not ovaries, but instead, are testes; during the embryonic stage of development, testes form in an androgen-independent process that occurs due to the influence of the SRY gene on the Y chromosome.[26][27] They may be located intra-abdominally, at the internal inguinal ring, or may herniate into the labia majora, often leading to the discovery of the condition.[1][28][29][30] Testes in affected women have been found to be atrophic upon gonadectomy.[31]

Testosterone produced by the testes cannot be directly used due to the mutant androgen receptor that characterizes CAIS; instead, it is aromatized into estrogen, which effectively feminizes the body and accounts for the normal female phenotype observed in CAIS.[1] However, up to 5% of individuals with CAIS do not have an AR mutation.[2] The receptor in question is encoded by the AR gene located on the X chromosome at Xq11–12. At least 15 different mutations were known in 2003, and they are all recessive, which makes the disease follow X-linked recessive inheritance.[20]

Immature sperm cells in the testes do not mature past an early stage, as sensitivity to androgens is required in order for spermatogenesis to complete.[32][33] Germ cell malignancy risk, once thought to be relatively high, is now thought to be approximately 2%.[34] Wolffian structures (the epididymides, vasa deferentia, and seminal vesicles) are typically absent, but will develop at least partially in approximately 30% of cases, depending on which mutation is causing the CAIS.[35] The prostate, like the external male genitalia, cannot masculinize in the absence of androgen receptor function, and thus remains in the female form.[18][36][37][38]

The Müllerian system (the fallopian tubes, uterus, and upper portion of the vagina) typically regresses due to the presence of anti-Müllerian hormone originating from the Sertoli cells of the testes.[19] These women are thus born without fallopian tubes, a cervix, or a uterus,[19] and the vagina ends "blindly" in a pouch.[1] Müllerian regression does not fully complete in approximately one third of all cases, resulting in Müllerian "remnants".[19] Although rare, a few cases of women with CAIS and fully developed Müllerian structures have been reported. In one exceptional case, a 22-year-old with CAIS was found to have a normal cervix, uterus, and fallopian tubes.[39] In an unrelated case, a fully developed uterus was found in a 22-year-old adult with CAIS.[38]

Other subtle differences that have been reported include slightly longer limbs and larger hands and feet due to a proportionally greater stature than unaffected women,[40][41][42] larger teeth,[43][44] minimal or no acne,[45] well developed breasts,[46] a greater incidence of meibomian gland dysfunction (i.e. dry eye syndromes and light sensitivity),[47] and dry skin and hair resulting from a lack of sebum production.[48]

Endocrine

Hormone levels have been reported in gonadally intact CAIS women in a number of studies.[49][50] Hormone levels are similar to those of males, including high testosterone levels and relatively low estradiol levels.[49][50] However, luteinizing hormone (LH) levels are elevated while sex hormone-binding globulin (SHBG) levels are more consistent with those of females.[49][50][51] Women with CAIS have low levels of progesterone similarly to males.[52][53][54] The production rates of testosterone, estradiol, and estrone have been reported to be higher in gonadally intact CAIS women than in men.[55][56]

Шаблон:Hormone levels in gonadally intact adolescent and adult females with complete androgen insensitivity syndrome

Comorbidity

Файл:Histopathology of androgen insensitivity.jpg
Histopathology of testicular tissue showing immature germ cells and spermatagonia with decreased tubular diameter. Scattered groups of Leydig cells appearing immature.[19]

All forms of androgen insensitivity, including CAIS, are associated with infertility, though exceptions have been reported for both the mild and partial forms.[4][5][7][57][58][59]

CAIS is associated with a decreased bone mineral density.[60][61][62][63][64][65] Some have hypothesized that the decreased bone mineral density observed in women with CAIS is related to the timing of gonadectomy and inadequate estrogen supplementation.[64] However, recent studies show that bone mineral density is similar whether gonadectomy occurs before or after puberty, and is decreased despite estrogen supplementation, leading some to hypothesize that the deficiency is directly attributable to the role of androgens in bone mineralization.[60][61][62][63]

CAIS is also associated with an increased risk for gonadal tumors (e.g. germ cell malignancy) in adulthood if gonadectomy is not performed.[34][66][67][68] The risk of malignant germ cell tumors in women with CAIS increases with age and has been estimated to be 3.6% at 25 years and 33% at 50 years.[68] The incidence of gonadal tumors in childhood is thought to be relatively low; a recent review of the medical literature[66] found that only three cases of malignant germ cell tumors in prepubescent girls have been reported in association with CAIS in the last 100 years. Some have estimated the incidence of germ cell malignancy to be as low as 0.8% before puberty.[1]

Vaginal hypoplasia, a relatively frequent finding in CAIS and some forms of PAIS,[23][25] is associated with sexual difficulties including vaginal penetration difficulties and dyspareunia.[21][25]

At least one study indicates that individuals with an intersex condition may be more prone to psychological difficulties, due at least in part to parental attitudes and behaviors,[69] and concludes that preventative long-term psychological counseling for parents as well as for affected individuals should be initiated at the time of diagnosis.

Lifespan is not thought to be affected by AIS.[1]

Despite the well-developed breasts in CAIS women, and for reasons that are not well-understood, breast cancer has never been reported in CAIS women and does not seem to occur or occurs only rarely.[70][71][72][73][74][75] Only a case report of juvenile fibroadenoma exists.[70][72][76] A few cases of breast cancer have been reported in individuals with partial androgen insensitivity syndrome however.[73][77][78]

Diagnosis

Шаблон:Main

Файл:Complete androgen insensitivity presenting with inguinal hernia.jpg
Bilateral inguinal hernia. CAIS is not usually suspected until after puberty unless an inguinal hernia presents.[79]

CAIS can only be diagnosed in normal phenotypic females.[2] It is not usually suspected unless the menses fail to develop at puberty, or an inguinal hernia presents during premenarche.[1][2] As many as 1–2% of prepubertal girls that present with an inguinal hernia will also have CAIS.[1][19]

A diagnosis of CAIS or Swyer syndrome can be made in utero by comparing a karyotype obtained by amniocentesis with the external genitalia of the fetus during a prenatal ultrasound.[2][80] Many infants with CAIS do not experience the normal, spontaneous neonatal testosterone surge, a fact which can be diagnostically exploited by obtaining baseline luteinizing hormone and testosterone measurements, followed by a human chorionic gonadotropin (hCG) stimulation test.[1]

The main differentials for CAIS are complete gonadal dysgenesis (Swyer syndrome) and Müllerian agenesis (Mayer-Rokitansky-Kuster-Hauser syndrome or MRKH).[1][25] Both CAIS and Swyer syndrome are associated with a 46,XY karyotype, whereas MRKH is not; MRKH can thus be ruled out by checking for the presence of a Y chromosome, which can be done either by fluorescence in situ hybridization (FISH) analysis or on full karyotype.[1] Swyer syndrome is distinguished by the presence of a uterus, poor breast development and shorter stature.[1] The diagnosis of CAIS is confirmed when androgen receptor (AR) gene sequencing reveals a mutation, although up to 5% of individuals with CAIS do not have an AR mutation.[2]

Up until the 1990s, a CAIS diagnosis was often hidden from the affected individual, the individual's family, or both.[18] It is current practice to disclose the genotype at the time of diagnosis, particularly when the affected girl is at least of adolescent age.[18] If the affected individual is a child or infant, it is generally up to the parents, often in conjunction with a psychologist, to decide when to disclose the diagnosis.[18]

Management

Management of AIS is currently limited to symptomatic management; methods to correct a malfunctioning androgen receptor protein that result from an AR gene mutation are not currently available. Areas of management include sex assignment, genitoplasty, gonadectomy in relation to tumor risk, hormone replacement therapy, and genetic and psychological counseling. Non-consensual interventions are still often performed, although general awareness on the resulting psychological traumatization is rising.[81]

Sex assignment and sexuality

Most individuals with CAIS are raised as females.[1] They are born phenotypically female and are usually heterosexual with a female gender identity;[41][82] however, at least two case studies have reported male gender identity in individuals with CAIS.[82][83]

Файл:Results of vaginal lengthening by pressure dilation methods.jpg
Vaginal length in 8 women with CAIS before and after dilation therapy as first line treatment. The normal reference range (shaded) is derived from 20 control women. Duration and extent of therapy varied; the median time to completion of treatment was 5.2 months, and the median number of 30-minute dilations per week was 5.[23]

Dilation therapy

Most cases of vaginal hypoplasia associated with CAIS can be corrected using non-surgical pressure dilation methods.[23][25] The elastic nature of vaginal tissue, as demonstrated by its ability to accommodate the differences in size between a tampon, a penis, and a baby's head,[84] make dilation possible even in cases when the vaginal depth is significantly compromised.[23][25] Treatment compliance is thought to be critical to achieve satisfactory results.[21][23][25] Dilation can also be achieved via the Vecchietti procedure, which stretches vaginal tissues into a functional vagina using a traction device that is anchored to the abdominal wall, subperitoneal sutures, and a mold that is placed against the vaginal dimple.[25] Vaginal stretching occurs by increasing the tension on the sutures, which is performed daily.[25] The non-operative pressure dilation method is currently recommended as the first choice, since it is non-invasive, and highly successful.[25] Vaginal dilation should not be performed before puberty.[34]

Gonadectomy

While it was often recommended that women with CAIS eventually undergo gonadectomy to mitigate cancer risk,[1] there are differing opinions regarding the necessity and timing of gonadectomy.[85] The risk of malignant germ cell tumors in women with CAIS increases with age and has been estimated to be 3.6% at 25 years and 33% at 50 years.[68] However, only three cases of malignant germ cell tumors in prepubescent girls with CAIS have been reported in the last 100 years.[66] The youngest of these girls was 14 years old.[86] Individuals with CAIS naturally go through female puberty, via the conversion of testosterone into estrogens, removing internal testis artificially makes someone reliant on hormone replacement therapy, as such a gonadectomy should never be performed on an infant.[87][88][89] Many individuals with CAIS, choose to go on testosterone as the body naturally converts it to estrogen, which can help alleviate symptoms such as nausea.[90]

If gonadectomy is performed early, then puberty must be artificially induced using gradually increasing doses of estrogen.[1] If gonadectomy is performed late, then puberty will occur on its own, due to the aromatization of testosterone into estrogen.[1] At least one organization, the Australasian Paediatric Endocrine Group, classifies the cancer risk associated with CAIS as low enough to recommend against gonadectomy, although it warns that the cancer risk is still elevated above the general population, and that ongoing cancer monitoring is essential.[85] Some choose to perform gonadectomy if and when inguinal hernia presents.[1] Estrogen replacement therapy is critical to minimize bone mineral density deficiencies later in life.[62][64]

Hormone replacement therapy

Some have hypothesized that supraphysiological levels of estrogen may reduce the diminished bone mineral density associated with CAIS.[62] Data has been published that suggests affected women who were not compliant with estrogen replacement therapy, or who had a lapse in estrogen replacement, experienced a more significant loss of bone mineral density.[61][62] Progestin replacement therapy is seldom initiated, due to the absence of a uterus.[1] Androgen replacement has been reported to increase a sense of well-being in gonadectomized women with CAIS, although the mechanism by which this benefit is achieved is not well understood.[1]

Counseling

It is no longer common practice to hide a diagnosis of CAIS from the affected individual or her family.[18] Parents of children with CAIS need considerable support in planning and implementing disclosure for their child once the diagnosis has been established.[1][18] For parents with young children, information disclosure is an ongoing, collaborative process requiring an individualized approach that evolves in concordance with the child's cognitive and psychological development.[1] In all cases, the assistance of a psychologist experienced in the subject is recommended.[1][18]

Neovaginal construction

Файл:Inflatable vaginal expander.jpg
Vaginal expander ZSI 200 NS
Файл:ZSI 200 NS Vaginal Expander in Vagina.jpg
ZSI 200 NS vaginal expander stretching the female vagina

Many surgical procedures have been developed to create a neovagina, but none of them are ideal.[25] Surgical intervention should only be considered after non-surgical pressure dilation methods have failed to produce a satisfactory result.[25] Neovaginoplasty can be performed using skin grafts, a segment of bowel, ileum, peritoneum, an absorbable adhesion barrier (Intercede, made by Johnson & Johnson),[91][92] buccal mucosa, amnion, dura mater.[25][93][94] or with the support of vaginal stents/expanders.[95][96] Success of such methods should be determined by sexual function, and not just by vaginal length, as has been done in the past.[94] Ileal or cecal segments may be problematic because of a shorter mesentery, which may produce tension on the neovagina, leading to stenosis.[94] The sigmoid neovagina is thought to be self-lubricating, without the excess mucus production associated with segments of small bowel.[94] Vaginoplasty may create scarring at the introitus (the vaginal opening), which requires additional surgery to correct. Vaginal dilators are required postoperatively to prevent vaginal stenosis from scarring.[23][25] Inflatable vaginal stents are placed in the vagina deflated and then gently inflated.[97] Other complications include bladder and bowel injuries.[25] Yearly exams are required as neovaginoplasty carries a risk of carcinoma,[25] although carcinoma of the neovagina is uncommon.[93][94] Neither neovaginoplasty nor vaginal dilation should be performed before puberty.[25][34]

Prognosis

Challenges presented to people affected by this condition include: psychologically coming to terms with the condition, difficulties with sexual function, infertility. Long-term studies indicate that with appropriate medical and psychological treatment, women with CAIS can be satisfied with their sexual function and psychosexual development.[41] CAIS women can lead active lives and expect a normal lifespan.

Epidemiology

It is estimated that CAIS occurs in 1 in 20,400 to 1 in 99,000 individuals with a 46,XY karyotype.[98][99]

Nomenclature

Шаблон:Main

Historically, CAIS has been referred to in the literature under a number of other names, including testicular feminization [syndrome] (deprecated) and Morris syndrome.[100][101] PAIS has also been referred to as Reifenstein syndrome, which should not be confused with CAIS.[100][101]

History

The first definitive description of CAIS was reported in 1817.[102][103] The condition became more widely known after it was reviewed and named testicular feminization by American gynecologist John McLean Morris in 1953.[103]

People with CAIS

See also

References

Шаблон:Reflist

External links

Шаблон:Medical resources

Information

Шаблон:Gonadal disorder Шаблон:X-linked disorders Шаблон:Intracellular receptor deficiencies

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  1. ↑ 1,00 1,01 1,02 1,03 1,04 1,05 1,06 1,07 1,08 1,09 1,10 1,11 1,12 1,13 1,14 1,15 1,16 1,17 1,18 1,19 1,20 1,21 1,22 1,23 1,24 1,25 1,26 Ошибка цитирования Неверный тег <ref>; для сносок 2006 hughes 20 не указан текст
  2. ↑ 2,0 2,1 2,2 2,3 2,4 2,5 2,6 2,7 Ошибка цитирования Неверный тег <ref>; для сносок 2008 galani 7 не указан текст
  3. ↑ 3,0 3,1 Ошибка цитирования Неверный тег <ref>; для сносок 1995 quigley 16 не указан текст
  4. ↑ 4,0 4,1 Ошибка цитирования Неверный тег <ref>; для сносок 2002 giwercman 87 не указан текст
  5. ↑ 5,0 5,1 5,2 Ошибка цитирования Неверный тег <ref>; для сносок 2008 zuccarello 68 не указан текст
  6. ↑ 6,0 6,1 Ошибка цитирования Неверный тег <ref>; для сносок 2006 ferlin 65 не указан текст
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  8. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2001 giwercman 54 не указан текст
  9. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2003 lund 79 не указан текст
  10. ↑ Шаблон:Cite journal
  11. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2010 ozulker 24 не указан текст
  12. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2007 davis-dao 92 не указан текст
  13. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2005 kawate 90 не указан текст
  14. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2005 gottlieb 10 не указан текст
  15. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1999 ahmed 80 не указан текст
  16. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1976 simpson не указан текст
  17. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2000 gilbert не указан текст
  18. ↑ 18,0 18,1 18,2 18,3 18,4 18,5 18,6 18,7 Ошибка цитирования Неверный тег <ref>; для сносок 2008 oakes 21 не указан текст
  19. ↑ 19,0 19,1 19,2 19,3 19,4 19,5 Ошибка цитирования Неверный тег <ref>; для сносок 2009 nichols 91 не указан текст
  20. ↑ 20,0 20,1 Ошибка цитирования Неверный тег <ref>; для сносок 2003 melo 88 не указан текст
  21. ↑ 21,0 21,1 21,2 Ошибка цитирования Неверный тег <ref>; для сносок 2003 minto 80 не указан текст
  22. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1997 sinnecker 156 не указан текст
  23. ↑ 23,0 23,1 23,2 23,3 23,4 23,5 23,6 Ошибка цитирования Неверный тег <ref>; для сносок 2007 ismail-pratt 22 не указан текст
  24. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1995 weber 86 не указан текст
  25. ↑ 25,00 25,01 25,02 25,03 25,04 25,05 25,06 25,07 25,08 25,09 25,10 25,11 25,12 25,13 25,14 25,15 25,16 Ошибка цитирования Неверный тег <ref>; для сносок 2010 quint 53 не указан текст
  26. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2006 achermann не указан текст
  27. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1995 simpson не указан текст
  28. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2008 decaestecker 89 не указан текст
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  31. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2001 boehmer 86 не указан текст
  32. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2001 johnston 142 не указан текст
  33. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2003 yong 9 не указан текст
  34. ↑ 34,0 34,1 34,2 34,3 Ошибка цитирования Неверный тег <ref>; для сносок 2006 hughes 91 не указан текст
  35. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2004 hannema 89 не указан текст
  36. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1999 roy 55 не указан текст
  37. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1999 kokontis 55 не указан текст
  38. ↑ 38,0 38,1 Ошибка цитирования Неверный тег <ref>; для сносок 2009 rajender 91 не указан текст
  39. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1999 chen 72 не указан текст
  40. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2006 papadimitriou 65 не указан текст
  41. ↑ 41,0 41,1 41,2 Ошибка цитирования Неверный тег <ref>; для сносок 2000 wisniewski 85 не указан текст
  42. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1984 varella 11 не указан текст
  43. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1980 alvesalo 32 не указан текст
  44. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1997 pietila 19 не указан текст
  45. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2002 sultan 20 не указан текст
  46. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1986 zachmann 108 не указан текст
  47. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2003 cermak 22 не указан текст
  48. ↑ Шаблон:Cite web
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  50. ↑ 50,0 50,1 50,2 Шаблон:Cite journal
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  52. ↑ Шаблон:Cite book
  53. ↑ Шаблон:Cite journal
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  55. ↑ Шаблон:Cite book
  56. ↑ Шаблон:Cite journal
  57. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2002 chu 87 не указан текст
  58. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2005 menakaya 25 не указан текст
  59. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2000 giwercman 85 не указан текст
  60. ↑ 60,0 60,1 Ошибка цитирования Неверный тег <ref>; для сносок 2007 danilovic 18 не указан текст
  61. ↑ 61,0 61,1 61,2 Ошибка цитирования Неверный тег <ref>; для сносок 2006 sobel 91 не указан текст
  62. ↑ 62,0 62,1 62,2 62,3 62,4 Ошибка цитирования Неверный тег <ref>; для сносок 2000 marcus 85 не указан текст
  63. ↑ 63,0 63,1 Ошибка цитирования Неверный тег <ref>; для сносок 1998 bertelloni 50 не указан текст
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  67. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1991 rutgers 10 не указан текст
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  71. ↑ Шаблон:Cite journal
  72. ↑ 72,0 72,1 Шаблон:Cite book
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  80. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2003 michailidis 76 не указан текст
  81. ↑ Шаблон:Cite journal
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  83. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 2010 tsjoen не указан текст
  84. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1996 grover 1 не указан текст
  85. ↑ 85,0 85,1 Submission 88 to the Australian Senate inquiry on the involuntary or coerced sterilisation of people with disabilities in Australia, Australasian Paediatric Endocrine Group (APEG), 27 June 2013
  86. ↑ Ошибка цитирования Неверный тег <ref>; для сносок 1989 hurt 161 не указан текст
  87. ↑ Шаблон:Cite web
  88. ↑ Шаблон:Cite journal
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  94. ↑ 94,0 94,1 94,2 94,3 94,4 Ошибка цитирования Неверный тег <ref>; для сносок 2008 breech не указан текст
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