Английская Википедия:Cyclodiol
Шаблон:Short description Шаблон:Drugbox
Cyclodiol (developmental code name ZK-115194; also known as 14α,17α-ethano-17β-estradiol) is a synthetic estrogen which was studied in the 1990s and was never marketed.[1][2][3] It is a derivative of estradiol with a bridge between the C14α and C17α positions.[1][2][3][4] Cyclodiol has 100% of the relative binding affinity of estradiol for the human ERα and similar transactivational capacity as estradiol at the receptor.[1] It has comparable potency to estradiol when administered by subcutaneous injection.[1] The drug shows genotoxicity similarly to estradiol.[1][4] Cyclodiol showed an absolute bioavailability of 33 ± 19% and an elimination half-life of 28.7 hours in pharmacokinetic studies in women.[2]
See also
References
Шаблон:Estrogen receptor modulators
Шаблон:Steroid-stub Шаблон:Genito-urinary-drug-stub
